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DFF dissociates from importin-alpha:importin-beta
Stable Identifier
R-HSA-9029667
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptosis induced DNA fragmentation (Homo sapiens)
DFF dissociates from importin-alpha:importin-beta (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on known mechanism of importin-alpha:importin-beta mode of action, cargo imported to the nucleus dissociates from the importin alpha/beta complex in a Ran:GTP-dependent manner. Dissociation of the DFF complex from the importin alpha/beta complex is therefore assumed. Ran:GTP is not shown as its role has not been studied in the context of the DFF complex (Neimanis et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17938174
Sequence elements in both subunits of the DNA fragmentation factor are essential for its nuclear transport
Kahle, J
,
Neimanis, S
,
Doenecke, D
,
Albig, W
J Biol Chem
2007
Participants
Input
DFF:associated with the importin-alpha:importin-beta complex [nucleoplasm]
(Homo sapiens)
Output
DFFA:DFFB [nucleoplasm]
(Homo sapiens)
importin-alpha:importin-beta complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Apoptosis induced DNA fragmentation (Homo sapiens)
Orthologous Events
DFF dissociates from importin-alpha:importin-beta (Bos taurus)
DFF dissociates from importin-alpha:importin-beta (Canis familiaris)
DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)
DFF dissociates from importin-alpha:importin-beta (Gallus gallus)
DFF dissociates from importin-alpha:importin-beta (Mus musculus)
DFF dissociates from importin-alpha:importin-beta (Rattus norvegicus)
DFF dissociates from importin-alpha:importin-beta (Sus scrofa)
DFF dissociates from importin-alpha:importin-beta (Xenopus tropicalis)
Authored
Matthews, L (2008-01-29)
Reviewed
Widlak, P (2008-05-08)
Created
Orlic-Milacic, M (2017-11-21)
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