BDNF-mediated activation of NTRK2 increases phosphorylation of voltage gated sodium channels by FYN, resulting in decrease of sodium currents (Ahn et al. 2007).
FYN activation downstream of NTRK2 is implicated in olygodendrocyte myelination and contributes to BDNF-induced activation of ERK1/2 (MAPK3/1) through an unknown mechanism (Peckham et al. 2015).
Besides acting downstream of NTRK2, FYN and other SRC kinases, activated by other receptors such as GPCRs, may phosphorylate NTRK2 and enhance its catalytic activity (Rajagopal and Chao 2006, Huang and McNamara 2010).
He, J, Mizuno, M, Nabeshima, T, Nakajima, A, Yamada, K
Kilpatrick, TJ, Gonsalvez, D, Giuffrida, L, Wood, R, Peckham, H, Murray, SS, Xiao, J, Ferner, A
Ahn, M, Catterall, WA, Beacham, D, Westenbroek, RE, Scheuer, T
Yamaguchi, T, Yamamoto, T, Narisawa-Saito, M, Silva, AJ, Nawa, H, Hayashi, T
Huang, YZ, McNamara, JO
Rajagopal, R, Chao, MV
Wada, K, Iwasaki, Y, Koizumi, S, Gay, B
© 2024 Reactome
