FYN-mediated phosphorylation of GRIN2B

Stable Identifier
R-HSA-9032601
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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FYN-mediated phosphorylation of GRIN2B
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Kinase activity of FYN is needed for tyrosine phosphorylation of the GRIN2B (also known as NR2B or GluN2B) subunit of the NMDA receptor complex in response to BDNF-mediated activation of the NTRK2 (TRKB) receptor (Mizuno et al. 2003, Li et al. 2017). The exact stoichiometry of this reaction and involvement of other proteins is not known.

Based on studies in rats, phosphorylation of GRIN2B by FYN downstream of NTRK2 signaling plays an important role in long term potentiation (LTP) and spatial memory formation (Mizuno et al. 2003) as well as in spinal LTP and pain hypersensitivity after peripheral nerve injury (Li et al. 2017).

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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:GRIN2B [plasma membrane]

Physical Entity
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:GRIN2B [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Fyn-mediated phosphorylation of Grin2b (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-15)
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