NTRK2 activates RAC1

Stable Identifier
R-HSA-9032759
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

DOCK3-mediated activation of RAC1 downstream of BDNF-induced signaling by NTRK2 (TRKB) plays a role in axonal growth and regeneration. DOCK3 can be recruited to the plasma membrane to activate RAC1 by binding to NTRK-associated FYN (Namekata et al. 2010). Alternatively, DOCK3 can, upon poorly elucidated RHOG activation by the BDNF:NTRK2 complex, bind to the RHOG:GTP complex and activate RAC1 in an ELMO1-dependent manner (Namekata et al. 2012).

Literature References
PubMed ID Title Journal Year
22734669 Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

Namekata, K, Watanabe, H, Guo, X, Kittaka, D, Kawamura, K, Kimura, A, Harada, C, Harada, T

Genes Cells 2012
20368433 Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

Namekata, K, Harada, C, Taya, C, Guo, X, Kimura, H, Parada, LF, Harada, T

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created