Reactome | NTRK2 activates RAC1

NTRK2 activates RAC1

Stable Identifier

R-HSA-9032759

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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DOCK3-mediated activation of RAC1 downstream of BDNF-induced signaling by NTRK2 (TRKB) plays a role in axonal growth and regeneration. DOCK3 can be recruited to the plasma membrane to activate RAC1 by binding to NTRK-associated FYN (Namekata et al. 2010). Alternatively, DOCK3 can, upon poorly elucidated RHOG activation by the BDNF:NTRK2 complex, bind to the RHOG:GTP complex and activate RAC1 in an ELMO1-dependent manner (Namekata et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
20368433	Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex Harada, T, Namekata, K, Guo, X, Harada, C, Parada, LF, Kimura, H, Taya, C	Proc. Natl. Acad. Sci. U.S.A.	2010
22734669	Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG Harada, T, Watanabe, H, Namekata, K, Kimura, A, Guo, X, Harada, C, Kawamura, K, Kittaka, D	Genes Cells	2012