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DOCK3 binds FYN associated with NTRK2
Stable Identifier
R-HSA-9032761
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FYN (Homo sapiens)
NTRK2 activates RAC1 (Homo sapiens)
DOCK3 binds FYN associated with NTRK2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DOCK3 binds to FYN activated downstream of BDNF-triggered NTRK2 (TRKB) signaling (Namekata et al. 2010).
Participants
Input
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane]
(Homo sapiens)
DOCK3 [cytosol]
(Homo sapiens)
Output
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane]
(Homo sapiens)
Participates
as an event of
NTRK2 activates RAC1 (Homo sapiens)
Inferred From
Dock3 binds Fyn associated with Ntrk2 (Mus musculus)
Authored
Orlic-Milacic, M (2018-01-05)
Reviewed
Castrén, E (2018-02-13)
Antila, H (2018-02-13)
Created
Orlic-Milacic, M (2017-12-18)
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