DOCK3 activates RAC1

Stable Identifier
R-HSA-9032798
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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DOCK3 activates RAC1
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DOCK3 activates RAC1 and contributes to recruitment of the RAC1 effector WASF1 (WAVE1). DOCK3-mediated activation of RAC1 is involved in BDNF-induced axonal sprouting (Namekata et al. 2010).

WASF1 has recently been implicated in endocytosis of the BDNF:NTRK2 (BDNF:TRKB) complex (Xu et al. 2016).

Literature References
PubMed ID Title Journal Year
20368433 Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

Harada, T, Namekata, K, Guo, X, Harada, C, Parada, LF, Kimura, H, Taya, C

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane]

Physical Entity
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
DOCK3 activates RAC1 (Bos taurus)
DOCK3 activates RAC1 (Canis familiaris)
DOCK3 activates RAC1 (Gallus gallus)
DOCK3 activates RAC1 (Mus musculus)
DOCK3 activates RAC1 (Rattus norvegicus)
DOCK3 activates RAC1 (Sus scrofa)
DOCK3 activates RAC1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-18)
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