Ubiquitinated PEX5 isoform L (Ub:PEX5L) is released from the peroxisomal membrane Docking and Translocation Module by PEX1:PEX6:PEX26 (the peroxisomal AAA ATPase complex, receptor export module) (Tamura et al. 2014, Law et al. 2017, also inferred from yeast homologs). PEX1 and PEX6 form a cytosolic hexameric ring that is anchored to the peroxisomal membrane by PEX26. Hydrolysis of ATP by PEX1 and PEX6 appears to cause a conformational change in PEX1:PEX6:PEX26 that removes Ub:PEX5L from the peroxisomal membrane and into the cytosol (reviewed in Saffert et al. 2017). ZFAND6 probably binds ubiquitinated PEX5 and PEX6 and acts as an export factor (Miyata et al. 2012). Export of PEX7 back to the cytosol requires export of PEX5L but PEX7 and PEX5L appear to be exported separately (Rodrigues et al. 2014).
Law, KB, Bronte-Tinkew, D, Di Pietro, E, Snowden, A, Jones, RO, Moser, A, Brumell, JH, Braverman, N, Kim, PK
Tamura, S, Matsumoto, N, Takeba, R, Fujiki, Y
Miyata, N, Okumoto, K, Mukai, S, Noguchi, M, Fujiki, Y
Rodrigues, TA, Alencastre, IS, Francisco, T, Brites, P, Fransen, M, Grou, CP, Azevedo, JE
Saffert, P, Enenkel, C, Wendler, P
Tamura, S, Okumoto, K, Toyama, R, Shimozawa, N, Tsukamoto, T, Suzuki, Y, Osumi, T, Kondo, N, Fujiki, Y
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