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NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
Stable Identifier
R-HSA-9034727
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through PI3K (Homo sapiens)
Activated NTRK3 binds IRS1 (Homo sapiens)
(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC):IRS1 [plasma membrane] (Homo sapiens)
(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated NTRK3 binds PI3K (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated NTRK3 binds SRC (Homo sapiens)
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated NTRK3 promotes SRC autophosphorylation (Homo sapiens)
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC,(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC):IRS1 [plasma membrane] (Homo sapiens)
(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated NTRK3 signals through PLCG1 (Homo sapiens)
Activated NTRK3 binds PLCG1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated PCLG1 dissociates from NTRK3 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 phosphorylates PLCG1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Activated NTRK3 signals through RAS (Homo sapiens)
Activated NTRK3 binds SHC1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 activates RAS through SHC1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 binds GRB2:SOS1 through SHC1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTRK3 phosphorylates SHC1 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
NTF3 activates NTRK3 signaling (Homo sapiens)
NTRK3 dimers trans-autophosphorylate (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane] (Homo sapiens)
Participants
components
NTF3 homodimer [extracellular region]
(Homo sapiens)
x 2
p-5Y-NTRK3 [plasma membrane]
(Homo sapiens)
Participates
as an input of
Activated NTRK3 binds SHC1 (Homo sapiens)
Activated NTRK3 binds SRC (Homo sapiens)
Activated NTRK3 binds PLCG1 (Homo sapiens)
PTPRO dephosphorylate NTRK3 (Gallus gallus)
Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
Activated NTRK3 binds PI3K (Homo sapiens)
as a component of
NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Homo sapiens)
as a candidate of
(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane] (Homo sapiens)
as an output of
Activated PCLG1 dissociates from NTRK3 (Homo sapiens)
NTRK3 dimers trans-autophosphorylate (Homo sapiens)
Inferred To
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Bos taurus)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Mus musculus)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Rattus norvegicus)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Sus scrofa)
NTF3:p-5Y-NTRK3 homodimer [plasma membrane]
(Xenopus tropicalis)
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