Reactome | Activated NTRK3 signals through RAS

Activated NTRK3 signals through RAS

Stable Identifier

R-HSA-9034864

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Upon activation by NTF3 (NT-3), the receptor tyrosine kinase NTRK3 (TRKC) triggers RAS signaling through adaptor proteins SHC1 and GRB2 (Marsh and Palfrey 1996, Gunn-Moore et al. 1997, Yuen and Mobley 1999). ERK activation downstream of NTRK3 may increase cell motility through WAVE. The mechanism is not known (Gromnitza et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
8752100	Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons Marsh, HN, Palfrey, HC	J. Neurochem.	1996
29162704	Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation George, B, Weide, T, Gromnitza, S, Lepa, C, Pavenstädt, H, Schwab, A	FASEB J.	2018
9078261	Analysis of mitogen-activated protein kinase activation by naturally occurring splice variants of TrkC, the receptor for neurotrophin-3 Williams, AG, Gunn-Moore, FJ, Tavaré, JM	Biochem. J.	1997
10486198	Early BDNF, NT-3, and NT-4 signaling events Yuen, EC, Mobley, WC	Exp. Neurol.	1999

Participants

Events

Participates

as an event of

Signaling by NTRK3 (TRKC) (Homo sapiens)

Event Information

Go Biological Process

positive regulation of Ras protein signal transduction (0046579)

Cross References

BioModels Database

BIOMD0000000466, BIOMD0000000424, BIOMD0000000940, BIOMD0000000468

Authored

Orlic-Milacic, M (2018-01-02)

Reviewed

Tsoulfas, P (2018-05-09)

Created

Orlic-Milacic, M (2018-01-13)

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