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HC-TXN2 [mitochondrial matrix]
Stable Identifier
R-HSA-9035482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
TXN2 oxidised, TXN2 disulfide, Thioredoxin, mitochondrial, THIOM_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
CysS248-MPST:TXN2 dissociates (Homo sapiens)
HC-TXN2 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16195549
Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2
Smeets, A
,
Evrard, C
,
Landtmeters, M
,
Marchand, C
,
Knoops, B
,
Declercq, JP
Protein Sci.
2005
External Reference Information
External Reference
UniProt:Q99757 TXN2
Gene Names
TXN2, TRX2
Chain
transit peptide:1-59, chain:60-166
Reference Genes
BioGPS Gene:25828 TXN2
COSMIC (genes):TXN2 TXN2
CTD Gene:25828 TXN2
dbSNP Gene:25828 TXN2
ENSEMBL:ENSG00000100348 TXN2
HGNC:17772 TXN2
KEGG Gene (Homo sapiens):25828 TXN2
Monarch:25828 TXN2
NCBI Gene:25828 TXN2
OMIM:609063 TXN2
UCSC:Q99757 TXN2
Reference Transcript
RefSeq:NM_012473.3 TXN2
RefSeq:XM_006724226.1 TXN2
Other Identifiers
0000510088
11729650_a_at
16934558
1UVZ
1W4V
1W89
209077_at
209078_s_at
25828
32852_at
3959594
3959595
3959600
3959601
3959602
3959603
3959605
3959606
3959607
3959608
8075778
8681
994
A_23_P68899
AAB41631
AAF86467
AAH13726
AAH50610
AAN05576
AF276920
AF480262
AL022313
BC013726
BC050610
CAB008681
CAG30487
CAG46694
CAG46715
CCDS13928
CH471095
CR456601
CR541896
CR541917
EAW60103
ENSG00000100348
ENSP00000216185
ENSP00000385393
ENST00000216185
ENST00000216185.6
ENST00000403313
ENST00000403313.5
EntrezGene:25828
EntrezGene:TXN2
F8WDN2
g9280552_3p_a_at
GE59430
GE81803
GO:0000098
GO:0001666
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0006520
GO:0006662
GO:0006790
GO:0006950
GO:0006979
GO:0008113
GO:0008150
GO:0009056
GO:0009725
GO:0009749
GO:0014070
GO:0015035
GO:0016491
GO:0030425
GO:0031669
GO:0033743
GO:0042493
GO:0042592
GO:0043025
GO:0043226
GO:0044281
GO:0044877
GO:0045454
GO:0048678
GO:0055114
HGNC:17772
HPA000994
Hs.211929.0.S2_3p_at
ILMN_1654457
IPR005746
IPR013766
IPR017937
IPR036249
M0QXH0
MIM:609063
MIM:616811
NM_012473
NP_036605
PF00085
PH_hs_0012289
PR00421
TC22000709.hg
TXN2
TXN2-201
TXN2-202
U78678
U78678_at
UPI0000001BCB
XM_005261508
XM_006724226
XM_011530111
XP_005261565
XP_006724289
XP_011528413
Participant Of
output
CysS248-MPST:TXN2 dissociates
Other forms of this molecule
TXN2 [mitochondrial matrix]
2xHC-TXN2 [mitochondrial matrix]
Inferred To
HC-TXN2 [mitochondrial matrix] (Bos taurus)
HC-TXN2 [mitochondrial matrix] (Caenorhabditis elegans)
HC-TXN2 [mitochondrial matrix] (Canis familiaris)
HC-TXN2 [mitochondrial matrix] (Danio rerio)
HC-TXN2 [mitochondrial matrix] (Dictyostelium discoideum)
HC-TXN2 [mitochondrial matrix] (Gallus gallus)
HC-TXN2 [mitochondrial matrix] (Mus musculus)
HC-TXN2 [mitochondrial matrix] (Rattus norvegicus)
HC-TXN2 [mitochondrial matrix] (Sus scrofa)
HC-TXN2 [mitochondrial matrix] (Xenopus tropicalis)
Modified Residues
Name
Inter-chain Crosslink via half cystine at 90 and 93
Coordinate
90
PsiMod Name
half cystine [MOD:00798]
PsiMod Definition
A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.
Cross References
RefSeq
NP_036605.2
,
XP_006724289.1
OpenTargets
ENSG00000100348
GeneCards
Q99757
ZINC target
Q99757
PRO
Q99757
Orphanet
25267
PDB
1W4V
,
1UVZ
,
1W89
Interactors (78)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96HT8 MR1L1
0.696
5
UniProt:Q15555 MARE2
0.696
5
UniProt:Q9UPY8 MARE3
0.696
5
UniProt:Q96CD2 PPCDC
1
PPCDC [cytosol]
(R-HSA-196829)
0.696
5
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.696
5
UniProt:O43805 SSNA1
1
SSNA1 [cytosol]
(R-HSA-380255)
0.696
5
UniProt:P49247 RPIA
2
RPIA [cytosol]
(R-HSA-71304)
RPIA A61V [cytosol]
(R-HSA-5660009)
0.696
5
UniProt:P19474 TRIM21
1
TRIM21 [cytosol]
(R-HSA-976051)
0.696
5
UniProt:Q8IZE3 PACE1
0.666
4
UniProt:Q96D09 GASP2
0.621
3
UniProt:Q6RW13 AGTRAP
2
p-AGTRAP-BRAF fusion [cytosol]
(R-HSA-6802511)
AGTRAP-BRAF fusion [cytosol]
(R-HSA-6802262)
0.556
3
UniProt:Q9UJ41 RABGEF1
2
RABGEF1 [cytosol]
(R-HSA-8875419)
RABGEF1 [early endosome membrane]
(R-HSA-2029032)
0.556
3
UniProt:Q96M63 CC114
0.556
3
UniProt:P61289 PSME3
2
PSME3 [cytosol]
(R-HSA-68816)
PSME3 [nucleoplasm]
(R-HSA-174310)
0.556
3
UniProt:Q96CG3 TIFA
2
p-T9-TIFA [cytosol]
(R-HSA-9645512)
TIFA [cytosol]
(R-HSA-451582)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:Q8IZU0 FAM9B
0.556
3
UniProt:P63010 AP2B1
4
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
0.556
3
UniProt:Q96HR9 REEP6
1
REEP6 [endoplasmic reticulum membrane]
(R-HSA-8939719)
0.556
3
UniProt:P43364-2 MAGEA11
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q8IUH3 RBM45
0.556
3
UniProt:P32321 DCTD
1
DCTD [cytosol]
(R-HSA-73592)
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q8IZE3-2 SCYL3
0.488
2
UniProt:Q9NZQ9 TMOD4
1
TMOD4 [cytosol]
(R-HSA-5694030)
0.488
2
UniProt:Q8N2N9-4 ANKRD36B
0.488
2
UniProt:Q99750 MDFI
0.488
2
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.488
2
UniProt:Q6PI77 BHLH9
0.488
2
IntAct:EBI-17564855 ZSCAN32
0.488
2
UniProt:Q9Y605 MOFA1
0.488
2
UniProt:P01189 POMC
12
POMC(237-267) [extracellular region]
(R-HSA-167405)
POMC(237-241) [extracellular region]
(R-HSA-167407)
POMC(138-176) [extracellular region]
(R-HSA-388607)
POMC(138-150) [extracellular region]
(R-HSA-388593)
POMC(217-234) [extracellular region]
(R-HSA-388617)
POMC(77-87) [extracellular region]
(R-HSA-388618)
POMC(138-176) [cytosol]
(R-HSA-1502544)
POMC(138-176) K25* [extracellular region]
(R-HSA-5623536)
POMC(138-176) E79* [extracellular region]
(R-HSA-5623539)
POMC(138-176) R236G [extracellular region]
(R-HSA-5603387)
POMC(1-241) [secretory granule lumen]
(R-HSA-378943)
POMC(138-176) [secretory granule lumen]
(R-HSA-378965)
0.488
2
UniProt:Q9H0C1 ZMY12
0.488
2
UniProt:O75934 BCAS2
1
BCAS2 [nucleoplasm]
(R-HSA-5420902)
0.488
2
UniProt:Q96CS2 HAUS1
1
HAUS1 [cytosol]
(R-HSA-8855199)
0.488
2
UniProt:Q9BXL8 CDCA4
0.488
2
UniProt:Q96NT3-2 GUCD1
0.488
2
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.488
2
UniProt:P24844-2 MYL9
0.488
2
UniProt:Q5JR59-3 MTUS2
0.488
2
UniProt:Q96T49 PP16B
0.488
2
UniProt:O95571 ETHE1
1
ETHE1 [mitochondrial matrix]
(R-HSA-1614628)
0.488
2
UniProt:P80188 LCN2
2
LCN2 [extracellular region]
(R-HSA-5215934)
LCN2 [specific granule lumen]
(R-HSA-6799614)
0.488
2
UniProt:Q8IUH3-3 RBM45
0.488
2
UniProt:Q5I0X7 TTC32
0.488
2
UniProt:Q8NCU1 CC197
0.488
2
UniProt:Q5TD97 FHL5
0.488
2
UniProt:P43358 MAGA4
0.488
2
UniProt:Q9UFW8 CGBP1
0.488
2
UniProt:Q8NFW5 DMBX1
0.488
2
UniProt:Q9BX10 GTPBP2
2
GTPBP2 [platelet alpha granule lumen]
(R-HSA-8862960)
GTPBP2 [extracellular region]
(R-HSA-8863001)
0.488
2
UniProt:P63010-2 AP2B1
0.488
2
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.488
2
UniProt:Q8TD10 MIPO1
0.488
2
IntAct:EBI-18142120 NUTM1
0.488
2
UniProt:Q9P2A4 ABI3
0.488
2
UniProt:Q96HR9-2 REEP6
0.488
2
UniProt:Q6RW13-2 AGTRAP
0.488
2
UniProt:Q9H6J7-2 C11ORF49
0.488
2
UniProt:Q8N4Y2-3 CRACR2B
0.488
2
UniProt:A0PJX0 CIB4
0.488
2
UniProt:Q6ZN96 Q6ZN96
0.488
2
UniProt:Q9BRT2 UQCC2
0.488
2
UniProt:Q6FHY5 Q6FHY5
0.488
2
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.488
2
UniProt:Q9H668 STN1
0.488
2
UniProt:Q9BT25 HAUS8
1
HAUS8 [cytosol]
(R-HSA-8855198)
0.488
2
UniProt:A6NEM1 GG6L9
0.488
2
UniProt:Q674X7-2 KAZN
0.488
2
UniProt:O15479 MAGB2
0.488
2
UniProt:P02549 SPTA1
1
SPTA1 [cytosol]
(R-HSA-391563)
0.488
2
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.488
2
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.488
2
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.488
2
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.488
2
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