HC-TXN2 [mitochondrial matrix]

Stable Identifier
R-HSA-9035482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
TXN2 oxidised, TXN2 disulfide, Thioredoxin, mitochondrial, THIOM_HUMAN
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
16195549 Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2

Smeets, A, Evrard, C, Landtmeters, M, Marchand, C, Knoops, B, Declercq, JP

Protein Sci. 2005
External Reference Information
External Reference
UniProt:Q99757 TXN2
Gene Names
TXN2, TRX2
Chain
transit peptide:1-59, chain:60-166
Reference Genes
BioGPS Gene:25828 TXN2
COSMIC (genes):TXN2 TXN2
CTD Gene:25828 TXN2
dbSNP Gene:25828 TXN2
ENSEMBL:ENSG00000100348 TXN2
HGNC:17772 TXN2
KEGG Gene (Homo sapiens):25828 TXN2
Monarch:25828 TXN2
NCBI Gene:25828 TXN2
OMIM:609063 TXN2
UCSC:Q99757 TXN2
Reference Transcript
Other Identifiers
0000510088
11729650_a_at
16934558
209077_at
209078_s_at
25828
32852_at
3959594
3959595
3959600
3959601
3959602
3959603
3959605
3959606
3959607
3959608
8075778
A_23_P68899
GE59430
GE81803
GO:0000098
GO:0001666
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0006520
GO:0006662
GO:0006790
GO:0006950
GO:0006979
GO:0008113
GO:0008150
GO:0009056
GO:0009725
GO:0009749
GO:0014070
GO:0015035
GO:0016491
GO:0030425
GO:0031669
GO:0033743
GO:0042493
GO:0042592
GO:0043025
GO:0043226
GO:0044281
GO:0044877
GO:0045454
GO:0048678
GO:0055114
Hs.211929.0.S2_3p_at
ILMN_1654457
PH_hs_0012289
TC22000709.hg
U78678_at
g9280552_3p_a_at
Participant Of
output
Other forms of this molecule
TXN2 [mitochondrial matrix]
2xHC-TXN2 [mitochondrial matrix]
Inferred To
txn2 [mitochondrial matrix] (Danio rerio)
txn2 [mitochondrial matrix] (Xenopus tropicalis)
Txn2 [mitochondrial matrix] (Mus musculus)
Txn2 [mitochondrial matrix] (Rattus norvegicus)
2xHC-TXN2 [mitochondrial matrix] (Dictyostelium discoideum)
2xHC-TXN2 [mitochondrial matrix] (Gallus gallus)
TXN2 [mitochondrial matrix] (Bos taurus)
TXN2 [mitochondrial matrix] (Canis familiaris)
TXN2 [mitochondrial matrix] (Sus scrofa)
trx-2 [mitochondrial matrix] (Caenorhabditis elegans)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 90 and 93
Coordinate
90
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
OpenTargets
GeneCards
HPA
ZINC target
Ensembl
PRO
Orphanet
PDB
Interactors (78)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O43805 SSNA1  1 0.718 6
 UniProt:Q8N1B4 VPS52  1 0.718 6
 UniProt:Q96CD2 PPCDC  1 0.718 6
 UniProt:Q9UPY8 MARE3      0.718 6
 UniProt:P19474 TRIM21  1 0.718 6
 UniProt:Q15555 MARE2      0.718 6
 UniProt:P49247 RPIA  2 0.718 6
 UniProt:Q96HT8 MR1L1      0.718 6
 UniProt:Q8IZE3 PACE1      0.666 4
 UniProt:Q96D09 GASP2      0.666 4
 UniProt:Q6RW13 AGTRAP  2 0.556 3
 UniProt:Q8IZE3-2 SCYL3      0.556 3
 UniProt:Q9UJ41 RABGEF1  2 0.556 3
 UniProt:Q9NZQ9 TMOD4  1 0.556 3
 UniProt:Q8N2N9-4 ANKRD36B      0.556 3
 UniProt:Q99750 MDFI      0.556 3
 UniProt:Q8NHQ1 CEP70  1 0.556 3
 UniProt:Q6PI77 BHLH9      0.556 3
 IntAct:EBI-16434357 CCSB ORF ID      0.556 3
 UniProt:Q9Y605 MOFA1      0.556 3
 UniProt:Q96M63 CC114      0.556 3
 UniProt:Q9H0C1 ZMY12      0.556 3
 UniProt:P21673 SAT1  1 0.556 3
 UniProt:O75934 BCAS2  1 0.556 3
 UniProt:Q96CS2 HAUS1  1 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:Q9BXL8 CDCA4      0.556 3
 UniProt:P61289 PSME3  2 0.556 3
 UniProt:Q96NT3-2 GUCD1      0.556 3
 UniProt:Q7Z3Y8 KRT27  1 0.556 3
 UniProt:Q8N0S2 SYCE1  1 0.556 3
 UniProt:P24844-2 MYL9      0.556 3
 UniProt:Q5JR59-3 MTUS2      0.556 3
 UniProt:Q96T49 PP16B      0.556 3
 UniProt:O95571 ETHE1  1 0.556 3
 UniProt:Q96CG3 TIFA  2 0.556 3
 UniProt:P80188 LCN2  2 0.556 3
 UniProt:Q9UNE7 STUB1  1 0.556 3
 UniProt:Q8IUH3-3 RBM45      0.556 3
 UniProt:O43829 ZBT14      0.556 3
 UniProt:Q5I0X7 TTC32      0.556 3
 UniProt:Q8IZU0 FAM9B      0.556 3
 UniProt:Q8NCU1 CC197      0.556 3
 UniProt:Q5TD97 FHL5      0.556 3
 UniProt:P43358 MAGA4      0.556 3
 UniProt:P40855 PEX19  1 0.556 3
 UniProt:Q9UFW8 CGBP1      0.556 3
 IntAct:EBI-22314709 CCSB ORF ID      0.556 3
 UniProt:P63010 AP2B1  4 0.556 3
 UniProt:Q96HR9 REEP6  1 0.556 3
 UniProt:Q9BX10 GTPBP2  2 0.556 5
 UniProt:P43364-2 MAGEA11      0.556 3
 UniProt:P63010-2 AP2B1      0.556 3
 UniProt:Q9UBB9 TFIP11  1 0.556 3
 UniProt:Q8TD10 MIPO1      0.556 3
 UniProt:Q15654 TRIP6      0.556 3
 UniProt:Q9P2A4 ABI3      0.556 3
 UniProt:Q96HR9-2 REEP6      0.556 3
 UniProt:Q6RW13-2 AGTRAP      0.556 3
 UniProt:Q9H6J7-2 C11ORF49      0.556 3
 UniProt:Q8IUH3 RBM45      0.556 3
 UniProt:Q8N4Y2-3 CRACR2B      0.556 3
 UniProt:P32321 DCTD  1 0.556 3
 UniProt:A0PJX0 CIB4      0.556 3
 UniProt:Q6ZN96 Q6ZN96      0.556 3
 UniProt:Q9BRT2 UQCC2      0.556 3
 UniProt:Q6FHY5 Q6FHY5      0.556 3
 UniProt:Q5JR59 MTUS2      0.556 3
 UniProt:P35638 DDIT3  1 0.556 3
 UniProt:Q9H668 STN1  1 0.556 3
 UniProt:Q9BT25 HAUS8  1 0.556 3
 UniProt:Q6A162 KRT40  1 0.556 3
 UniProt:A6NEM1 GG6L9      0.556 3
 UniProt:Q674X7-2 KAZN      0.556 3
 UniProt:Q9HD42 CHMP1A  1 0.556 3
 UniProt:P01189 POMC  12 0.556 3
 UniProt:P02549 SPTA1  1 0.556 3
 UniProt:O15479 MAGB2      0.556 3
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