CysS248-MPST:TXN2 dissociates

Stable Identifier
R-HSA-9035484
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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A polysulfur chain may be produced at the catalytic site of CysS248-MPST. H2Sn is released after CysS248-MPST binds mitochondrial thioredoxin (TXN2) (Smeets et al. 2005, Yadav et al. 2013, Holzerova et al. 2016). The length of the sulfur chain released from MPST may vary depending on the availability of thioredoxin (Kimura 2016). When the interaction between MPST and thioredoxin is strong, the shorter form H2S can be released. Thioredoxin is now in the oxidised, disulfide form (HC-TXN2) and can be reduced by thioredoxin reductase in the presence of NADPH (Smeets et al. 2005, Yadav et al. 2013).

Literature References
PubMed ID Title Journal Year
23698001 Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase

Yadav, PK, Yamada, K, Chiku, T, Koutmos, M, Banerjee, R

J. Biol. Chem. 2013
24800864 Signaling molecules: hydrogen sulfide and polysulfide

Kimura, H

Antioxid. Redox Signal. 2015
16195549 Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2

Smeets, A, Evrard, C, Landtmeters, M, Marchand, C, Knoops, B, Declercq, JP

Protein Sci. 2005
26626369 Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

Holzerova, E, Danhauser, K, Haack, TB, Kremer, LS, Melcher, M, Ingold, I, Kobayashi, S, Terrile, C, Wolf, P, Schaper, J, Mayatepek, E, Baertling, F, Friedmann Angeli, JP, Conrad, M, Strom, TM, Meitinger, T, Prokisch, H, Distelmaier, F

Brain 2016
Participants
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Orthologous Events
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