Reactome | ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s

ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s

Stable Identifier

R-HSA-9036301

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s

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Binding of E2 to GPER induces the exchange of GDP for GTP on the G alpha (s) heterotrimer G protein, activating it (Filardo et al, 2007; Thomas et al, 2005; Revankar et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15539556	Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells Pang, Y, Thomas, P, Dong, J, Filardo, E J	Endocrinology	2005
17379646	Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane Filardo, E J, Pang, Y, Thomas, P, Quinn, J, Dong, J, Shaw, S, Graeber, C	Endocrinology	2007
15705806	A transmembrane intracellular estrogen receptor mediates rapid cell signaling Prossnitz, ER, Revankar, CM, Sklar, LA, Arterburn, JB, Cimino, DF	Science	2005