SRC,FYN phosphorylate NTRK2

Stable Identifier
R-HSA-9037040
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SRC,FYN phosphorylate NTRK2
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated SRC and, probably FYN, can phosphorylate NTRK2 (TRKB) on tyrosine residues Y706 and Y707 in the absence of ligand binding, thus increasing the catalytic activity of NTRK2 (Huang and McNamara 2010).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC,(MyrG-p-Y420-FYN-1) [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC,(MyrG-p-Y420-FYN-1) [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Src phosphorylates Ntrk2 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2018-02-16)
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