Reactome | Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

Stable Identifier

R-HSA-9038161

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG

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In addition to being a target of estrogen-dependent transcription, the progesterone receptor (PGR) interacts directly with ER alpha after stimulation with progesterone and modulates ESR1:ESTG binding (Ballare et al, 2003; Mohammed et al, 2015). Progesterone stimulation under estrogen-rich conditions promotes the release of PGR from the chaperone complex to facilitate interaction with ESR1 (Mohammed et al, 2015; reviewed in ).

Literature References

PubMed ID	Title	Journal	Year
12612073	Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cells Sancho, E, Uhrig, M, Auricchio, F, Di Domenico, M, Beato, M, Migliaccio, A, Bechtold, T, Ballaré, C	Mol. Cell. Biol.	2003
19274700	Breast cancer, estrogen receptor and ligands Bai, Z, Gust, R	Arch. Pharm. (Weinheim)	2009
26153859	Progesterone receptor modulates ERα action in breast cancer Tarulli, GA, Hadfield, J, Birrell, SN, Perou, CM, Hickey, TE, Serandour, AA, Launchbury, R, Pugh, M, Silva, G, Russell, IA, Bruna, A, Stingl, J, Caldas, C, Raj, GV, D'Santos, C, Saadi, A, Mohammed, H, Rueda, OM, Serandour, AA, Robinson, JL, Tilley, WD, Brown, GD, Stark, R, Menon, S, Carroll, JS	Nature	2015