Phosphorylation of STAT1 at Ser727

Stable Identifier
R-HSA-909552
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Kinases like Protein kinase C delta (PKC-delta) and Calcium/calmodulin-dependent protein kinase II (CaMK II ) can phosphorylate STAT1 at serine 727 (S727). This phosphorylation is not required for STAT1 homodimer formation, nuclear translocation and DNA binding. However, it is essential for the full transcriptional activation of STAT1.

Literature References
PubMed ID Title Journal Year
15322115 Protein kinase Cdelta regulates apoptosis via activation of STAT1

DeVries, TA, Kalkofen, RL, Matassa, AA, Reyland, ME

J Biol Chem 2004
11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma

Nair, JS, DaFonseca, CJ, Tjernberg, A, Sun, W, Darnell JE, Jr, Chait, BT, Zhang, JJ

Proc Natl Acad Sci U S A 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of CaMKII and PKC-delta [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created