Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y690-STAT2 [nucleoplasm]
Stable Identifier
R-HSA-909673
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-STAT2, phospho STAT2 (Y690)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Expression of IFN-induced genes (Homo sapiens)
ISGF3 [nucleoplasm] (Homo sapiens)
p-STAT2:p-STAT1 [nucleoplasm] (Homo sapiens)
p-Y690-STAT2 [nucleoplasm] (Homo sapiens)
ISGF3 bound to ISRE promotor elements [nucleoplasm] (Homo sapiens)
ISGF3 [nucleoplasm] (Homo sapiens)
p-STAT2:p-STAT1 [nucleoplasm] (Homo sapiens)
p-Y690-STAT2 [nucleoplasm] (Homo sapiens)
ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)
ISGF3 [nucleoplasm] (Homo sapiens)
p-STAT2:p-STAT1 [nucleoplasm] (Homo sapiens)
p-Y690-STAT2 [nucleoplasm] (Homo sapiens)
ISGF3 bound to ISRE promotor elements [nucleoplasm] (Homo sapiens)
ISGF3 [nucleoplasm] (Homo sapiens)
p-STAT2:p-STAT1 [nucleoplasm] (Homo sapiens)
p-Y690-STAT2 [nucleoplasm] (Homo sapiens)
Translocation of ISGF3 complex to nucleus (Homo sapiens)
ISGF3 [nucleoplasm] (Homo sapiens)
p-STAT2:p-STAT1 [nucleoplasm] (Homo sapiens)
p-Y690-STAT2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52630 STAT2
Gene Names
STAT2
Chain
chain:1-851
Reference Genes
BioGPS Gene:6773 STAT2
COSMIC (genes):STAT2 STAT2
CTD Gene:6773 STAT2
dbSNP Gene:6773 STAT2
ENSEMBL:ENSG00000170581 STAT2
ENSEMBL_homo_sapiens_GENE:ENSG00000170581.15 STAT2
HGNC:11363 STAT2
KEGG Gene (Homo sapiens):6773 STAT2
Monarch:6773 STAT2
NCBI Gene:6773 STAT2
OMIM:600556 STAT2
UCSC:P52630 STAT2
Reference Transcript
RefSeq:NM_005419.3 STAT2
RefSeq:NM_198332.1 STAT2
Other Identifiers
11718652_a_at
11752794_a_at
11752795_x_at
11755147_s_at
1244_at
16766093
205170_PM_at
205170_at
217199_3p_s_at
217199_PM_s_at
217199_s_at
225636_PM_at
225636_at
3457753
3457754
3457755
3457756
3457757
3457758
3457759
3457760
3457763
3457765
3457766
3457767
3457770
3457772
3457775
3457777
3457778
3457779
3457781
3457782
3457784
3457785
3457786
3457787
3457788
3457789
3457790
36770_at
52062_f_at
6773
7964119
91777_s_at
A_23_P76090
A_33_P3213064
GE58983
GO:0000785
GO:0000978
GO:0000981
GO:0001932
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006952
GO:0007005
GO:0007165
GO:0007166
GO:0007259
GO:0023052
GO:0036211
GO:0042127
GO:0042802
GO:0043226
GO:0043434
GO:0044389
GO:0045944
GO:0048856
GO:0051607
GO:0060337
GO:0060339
GO:0070721
GO:0071310
GO:0090140
GO:0090575
GO:0098542
GO:0140110
HMNXSV003000479
HMNXSV003003633
HMNXSV003007001
Hs.247981.0.S1_3p_s_at
Hs.42491.0.S1_3p_at
ILMN_1690921
PH_hs_0028948
TC12001602.hg
U18671_rna1_at
g4885614_3p_at
Participates
as a component of
p-STAT2:p-STAT1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-Y690-STAT2 [cytosol]
STAT2 [cytosol]
p-Y-STAT2 [cytosol]
Inferred To
phospho-Stat2 [nucleoplasm]
(Mus musculus)
phospho-Stat2 [nucleoplasm]
(Rattus norvegicus)
phospho-STAT2 [nucleoplasm]
(Bos taurus)
phospho-STAT2 [nucleoplasm]
(Sus scrofa)
phospho-stat2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 690
Coordinate
690
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_005410.1
,
NP_938146.1
OpenTargets
ENSG00000170581
GeneCards
P52630
HPA
ENSG00000170581-STAT2
Ensembl
ENST00000557235
,
ENSG00000170581
,
ENSP00000450751
,
ENSP00000315768
,
ENST00000314128
,
ENST00000698192
,
ENSP00000513599
PRO
P52630
Pharos - Targets
P52630
Orphanet
23276
PDB
8T12
,
2KA4
,
6UX2
,
8T13
,
6WCZ
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.92
19
UniProt:Q00978 IRF9
2
IRF9 [nucleoplasm]
(R-HSA-913522)
IRF9 [cytosol]
(R-HSA-879183)
0.839
10
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.76
7
UniProt:P17181 IFNAR1
2
IFNAR1 [plasma membrane]
(R-HSA-877334)
p-Y466,Y481-IFNAR1 [plasma membrane]
(R-HSA-909675)
0.758
5
UniProt:P48551 IFNAR2
0.688
4
UniProt:P29597 TYK2
5
p-TYK2 [cytosol]
(R-HSA-8950424)
p-Y-TYK2 [cytosol]
(R-HSA-6784366)
TYK2 [cytosol]
(R-HSA-877348)
p-Y1054,Y1055-TYK2 [cytosol]
(R-HSA-909682)
p-Y1054-TYK2 [cytosol]
(R-HSA-1112598)
0.641
4
UniProt:P0C774 V
0.576
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.532
3
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.527
2
UniProt:Q6JEL2 KLH10
0.527
2
UniProt:Q9NSE4 IARS2
1
IARS2 [mitochondrial matrix]
(R-HSA-379571)
0.527
2
UniProt:O94782 USP1
3
USP1 [nucleoplasm]
(R-HSA-419546)
USP1(672-785) [nucleoplasm]
(R-HSA-5655474)
USP1(1-671) [nucleoplasm]
(R-HSA-5655484)
0.527
2
UniProt:P0C2W1 FBSP1
0.527
2
UniProt:O15357 INPPL1
1
INPPL1 [cytosol]
(R-HSA-913354)
0.527
3
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.527
3
UniProt:Q9BVL4 SELO
0.527
3
UniProt:Q9Y234 LIPT1
1
LIPT1 [mitochondrial matrix]
(R-HSA-6792623)
0.527
2
UniProt:Q997F2 V
0.527
2
UniProt:P02724 GYPA
1
GYPA [plasma membrane]
(R-HSA-8867204)
0.527
2
UniProt:Q6ZSG2 INSY2
0.527
2
UniProt:Q77PU6 U90
0.524
2
UniProt:P11207 V
0.508
2
UniProt:Q8TEW6 DOK4
1
DOK4 [cytosol]
(R-HSA-8847701)
0.488
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text