Reactome | p-Y690-STAT2 [cytosol]

p-Y690-STAT2 [cytosol]

Stable Identifier

R-HSA-909683

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-STAT2, phospho STAT2 (Y690)

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Phosphorylation of STAT1 (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-Y690-STAT2 [cytosol] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-STAT1:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        p-STAT2:p-STAT1 [cytosol] (Homo sapiens)
        
        p-Y690-STAT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52630 STAT2

Gene Names

STAT2

Chain

chain:1-851

Reference Genes

BioGPS Gene:6773 STAT2

COSMIC (genes):STAT2 STAT2

CTD Gene:6773 STAT2

dbSNP Gene:6773 STAT2

ENSEMBL:ENSG00000170581 STAT2

HGNC:11363 STAT2

KEGG:hsa:6773 STAT2

Monarch:6773 STAT2

NCBI Gene:6773 STAT2

OMIM:600556 STAT2

UCSC:P52630 STAT2

Reference Transcript

Other Identifiers

11718652_a_at

11752794_a_at

11752795_x_at

11755147_s_at

11760880_a_at

1244_at

16766093

205170_PM_at

205170_at

217199_3p_s_at

217199_PM_s_at

217199_s_at

225636_PM_at

225636_at

3457749

3457751

3457753

3457754

3457755

3457756

3457757

3457758

3457759

3457760

3457761

3457762

3457763

3457764

3457765

3457766

3457767

3457768

3457769

3457770

3457771

3457772

3457773

3457774

3457775

3457776

3457777

3457778

3457779

3457780

3457781

3457782

3457783

3457784

3457785

3457786

3457787

3457788

3457789

3457790

36770_at

52062_f_at

6773

7964119

91777_s_at

A_23_P76090

A_33_P3213064

GE58983

GO:0000785

GO:0000978

GO:0000981

GO:0001932

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006357

GO:0006952

GO:0007165

GO:0007166

GO:0007259

GO:0042127

GO:0042802

GO:0043226

GO:0043434

GO:0044389

GO:0045944

GO:0051607

GO:0060337

GO:0060339

GO:0070721

GO:0090140

GO:0090575

GO:0098542

GO:0140110

HMNXSV003000479

HMNXSV003003633

HMNXSV003007001

Hs.247981.0.S1_3p_at

Hs.247981.0.S1_3p_s_at

Hs.42491.0.S1_3p_at

ILMN_1690921

PH_hs_0028948

TC12001602.hg

U18671_rna1_at

g4885614_3p_at

Participates

as a component of

Other forms of this molecule

STAT2 [cytosol]

p-Y690-STAT2 [nucleoplasm]

p-Y-STAT2 [cytosol]

Inferred To

Homologues of p-Y690-STAT2 [cytosol] (Caenorhabditis elegans)

Homologues of p-Y690-STAT2 [cytosol] (Dictyostelium discoideum)

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-Stat2 [cytosol] (Mus musculus)

phospho-Stat2 [cytosol] (Rattus norvegicus)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

phospho-STAT2 [cytosol] (Bos taurus)

phospho-STAT2 [cytosol] (Canis familiaris)

phospho-STAT2 [cytosol] (Sus scrofa)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-stat2 [cytosol] (Xenopus tropicalis)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

phospho-p-Y690-STAT2 [cytosol] (Caenorhabditis elegans)

phospho-p-Y690-STAT2 [cytosol] (Dictyostelium discoideum)

phospho-p-Y690-STAT2 [cytosol] (Gallus gallus)

phospho-dstC [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 690

Coordinate

690

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005410.1, NP_938146.1

OpenTargets

ENSG00000170581

ENSEMBL

ENSP00000315768, ENSP00000513599, ENST00000698192, ENSP00000450751, ENST00000314128, ENST00000557235

HPA

ENSG00000170581-STAT2

PRO

P52630

Pharos - Targets

P52630

GlyGen

P52630

Orphanet

STAT2

PDB

6UX2, 6WCZ, 2KA4, 8T12, 8T13

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.92	19
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.839	10
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.76	7
UniProt:P17181 IFNAR1	2	IFNAR1 [plasma membrane] (R-HSA-877334) p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675)	0.758	5
UniProt:P48551 IFNAR2			0.688	4
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.641	4
UniProt:P0C774 V			0.576	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.532	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.527	2
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.527	3
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	3
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.527	2
UniProt:Q6ZSG2 INSY2			0.527	2
UniProt:P02724 GYPA	1	GYPA [plasma membrane] (R-HSA-8867204)	0.527	2
UniProt:Q997F2 V			0.527	2
UniProt:Q9BVL4 SELO			0.527	3
UniProt:P0C2W1 FBSP1			0.527	2
UniProt:O94782 USP1	3	USP1 [nucleoplasm] (R-HSA-419546) USP1(672-785) [nucleoplasm] (R-HSA-5655474) USP1(1-671) [nucleoplasm] (R-HSA-5655484)	0.527	2
UniProt:Q9NSE4 IARS2	1	IARS2 [mitochondrial matrix] (R-HSA-379571)	0.527	2
UniProt:Q6JEL2 KLH10			0.527	2
UniProt:Q77PU6 U90			0.524	2
UniProt:P11207 V			0.508	2
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2

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