Release of p-STAT2:p-STAT1 dimer

Stable Identifier
R-HSA-909722
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Release of p-STAT2:p-STAT1 dimer
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The phosphorylated STAT2:STAT1 heterodimers thus formed disassociate from the IFNAR1 subunit and translocates to the nucleus.
Literature References
PubMed ID Title Journal Year
17351669 STAT activation and differential complex formation dictate selectivity of interferon responses

Szweykowska-Kulinska, Z, Wesoly, J, Bluyssen, HA

Acta Biochim Pol 2007
8621447 Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha

Stark, GR, Darnell JE, Jr, Qureshi, S, Li, X, Leung, S

J Biol Chem 1996
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Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-07)
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