Phosphorylation of STAT1

Stable Identifier
R-HSA-909726
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphotyrosine on STAT2 acts as docking site for STAT1 molecules. STAT1 binds to phosphorylated STAT2 and this is followed by STAT1 phosphorylation on tyrosine residue 701 (Y701). These STATs recruited to the phosporylated IFNAR1 form two distinct transcriptional activator complexes, namely, IFN-alpha-activated factor (AAF) and IFN-stimulated gene factor 3 (ISGF3). AAF is a homodimer of STAT1, whereas ISGF3 is a heterotrimeric complex of STAT1, STAT2 and IRF9 (also known as p48 or ISGF3gamma) (Honda et al. 2005).

Literature References
PubMed ID Title Journal Year
8232552 The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

Muller, M, Briscoe, J, Laxton, C, Guschin, D, Ziemiecki, A, Silvennoinen, O, Harpur, AG, Barbieri, G, Witthuhn, BA, Schindler, C

Nature 1993
10982844 Regulation of STAT1 nuclear export by Jak1

Mowen, K, David, M

Mol Cell Biol 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
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