Activation of JAK kinases

Stable Identifier
R-HSA-909729
Type
Reaction [transition]
Species
Homo sapiens
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The two chains IFNAR1 and IFNAR2 are pre-associated with the JAK kinases TYK2 and JAK1, respectively. Receptor heterodimerization brings these JAK kinases into close proximity and they are activated by reciprocal trans-phosphorylation. Tyr-1054 and Tyr-1055 within the activation loop of TYK2 sub-domain VII are critical for TYK2 activation. For JAK1 two tyrosine residues with in the KEYY motif (Tyr 1034 and Tyr 1035) of the kinase domain are thought to be transphosphorylated.

Literature References
PubMed ID Title Journal Year
8702790 Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

Gauzzi, MC, Velazquez, L, McKendry, R, Mogensen, KE, Fellous, M, Pellegrini, S

J Biol Chem 1996
9334213 A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state

Domanski, P, Fish, E, Nadeau, OW, Witte, M, Platanias, LC, Yan, H, Krolewski, J, Pitha, P, Colamonici, OR

J Biol Chem 1997
Participants
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Catalyst Activity
Title
protein tyrosine kinase activity of IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane]
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This event is regulated
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