Reactome | SUN2 [nuclear envelope]

SUN2 [nuclear envelope]

Stable Identifier

R-HSA-912382

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

SUN domain-containing protein 2, SUN2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UH99 SUN2

Gene Names

SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B

Chain

chain:1-717

Reference Genes

BioGPS Gene:25777 SUN2

COSMIC (genes):SUN2 SUN2

CTD Gene:25777 SUN2

dbSNP Gene:25777 SUN2

ENSEMBL:ENSG00000100242 SUN2

HGNC:14210 SUN2

KEGG Gene (Homo sapiens):25777 SUN2

Monarch:25777 SUN2

NCBI Gene:25777 SUN2

OMIM:613569 SUN2

UCSC:Q9UH99 SUN2

Reference Transcript

Other Identifiers

0005720546

11744355_a_at

11744446_a_at

11748048_a_at

11748049_x_at

11749479_a_at

11752062_a_at

16935142

16935176

212144_at

25777

35336_at

3960823

3960825

3960826

3960828

3960829

3960834

3960835

3960836

3960837

3960838

3960839

3960842

3960843

3960845

3960847

3960850

3960851

3960852

3960853

3960854

3960857

3960858

3960859

3960866

3960869

3960870

3960895

8076137

A_32_P194115

GE766443

GO:0000003

GO:0000228

GO:0000278

GO:0000784

GO:0000794

GO:0003674

GO:0005515

GO:0005521

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005637

GO:0005639

GO:0005694

GO:0005737

GO:0005768

GO:0006810

GO:0006998

GO:0007010

GO:0007049

GO:0007052

GO:0007097

GO:0008017

GO:0008092

GO:0008150

GO:0010008

GO:0016020

GO:0016021

GO:0021817

GO:0030154

GO:0030335

GO:0030674

GO:0030705

GO:0031022

GO:0031410

GO:0031965

GO:0032991

GO:0034993

GO:0040011

GO:0042802

GO:0043226

GO:0043495

GO:0048856

GO:0048870

GO:0051321

GO:0051642

GO:0061024

GO:0090286

GO:0090292

Hs.5898.1.S1_3p_at

ILMN_1783315

ILMN_2099301

PH_hs_0019297

TC22001495.hg

Participant Of

hasComponent

Telomere Attachment Plate [nuclear envelope]

input

Telomeres cluster at the nuclear membrane

Cross References

RefSeq

NP_001186509.1, NP_001186508.1, NP_056189.1

OpenTargets

ENSG00000100242

HPA

ENSG00000100242-SUN2

GeneCards

Q9UH99

Ensembl

ENSP00000385740, ENSP00000383992, ENSP00000385616, ENST00000406622, ENST00000405018, ENST00000405510, ENSG00000100242

PRO

Q9UH99

PDB

4DXT, 4DXR, 4DXS, 3UNP, 4FI9

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WXH0 SYNE2	1	SYNE2 [nuclear envelope] (R-HSA-912404)	0.768	8
UniProt:P20339 RAB5A	6	RAB5A [endosome membrane] (R-HSA-452257) RAB5A [cytosol] (R-HSA-2201187) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.738	5
UniProt:P51148 RAB5C	9	RAB5C [plasma membrane] (R-HSA-6806265) RAB5C [azurophil granule membrane] (R-HSA-6799338) RAB5C [cytosol] (R-HSA-8870413) GGC-RAB5C [cytosol] (R-HSA-8870436) GGC-RAB5C [early endosome membrane] (R-HSA-8875331) RAB5C [early endosome membrane] (R-HSA-8854157) RAB5C [cytoplasmic vesicle membrane] (R-HSA-434198) RAB5C [Golgi membrane] (R-HSA-434334) GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (R-HSA-8871129)	0.669	3
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.641	4
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.641	4
UniProt:Q8NF91 SYNE1	1	SYNE1 [nuclear envelope] (R-HSA-912352)	0.591	3
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.564	2
UniProt:P53618 COPB1	8	COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [tertiary granule membrane] (R-HSA-6800175) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [cytosol] (R-HSA-199995) COPB1 [transport vesicle] (R-HSA-6808736)	0.564	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.558	2
UniProt:Q8IXM6 NRM			0.556	3
UniProt:Q8NF91-1 SYNE1			0.524	2
UniProt:Q8WXH0-1 SYNE2			0.524	2
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.499	3

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