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SUN2 [nuclear envelope]
Stable Identifier
R-HSA-912382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
SUN domain-containing protein 2, SUN2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8TBX8 PIP4K2C
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
SUN2 [nuclear envelope] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
SUN2 [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UH99 SUN2
Gene Names
SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B
Chain
chain:1-717
Reference Genes
BioGPS Gene:25777 SUN2
COSMIC (genes):SUN2 SUN2
CTD Gene:25777 SUN2
dbSNP Gene:25777 SUN2
ENSEMBL:ENSG00000100242 SUN2
HGNC:14210 SUN2
KEGG:hsa:25777 SUN2
Monarch:25777 SUN2
NCBI Gene:25777 SUN2
OMIM:613569 SUN2
UCSC:Q9UH99 SUN2
Reference Transcript
RefSeq:NM_001199579.1 SUN2
RefSeq:NM_015374.2 SUN2
RefSeq:NM_001199580.1 SUN2
Other Identifiers
11744355_a_at
11744446_a_at
11748048_a_at
11748049_x_at
11749479_a_at
11752062_a_at
16935142
16935176
212144_PM_at
212144_at
25777
35336_at
3960821
3960823
3960825
3960826
3960828
3960829
3960831
3960832
3960833
3960834
3960835
3960836
3960837
3960838
3960839
3960840
3960841
3960842
3960843
3960845
3960846
3960847
3960850
3960851
3960852
3960853
3960854
3960855
3960856
3960857
3960858
3960859
3960866
3960867
3960868
3960869
3960870
3960895
8076137
A_32_P194115
GE766443
GE885007
GO:0000228
GO:0000781
GO:0000794
GO:0005515
GO:0005521
GO:0005634
GO:0005635
GO:0005637
GO:0005694
GO:0005768
GO:0007010
GO:0007018
GO:0007052
GO:0007097
GO:0008017
GO:0008092
GO:0010008
GO:0016020
GO:0021817
GO:0022414
GO:0030335
GO:0031022
GO:0031410
GO:0031965
GO:0034993
GO:0042802
GO:0043226
GO:0043495
GO:0051321
GO:0051642
GO:0060090
GO:0090292
GO:0140444
HMNXSV003046346
Hs.5898.1.S1_3p_at
ILMN_2099301
PH_hs_0019297
TC22001495.hg
Participates
as a component of
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
as an input of
Telomeres cluster at the nuclear membrane (Homo sapiens)
Cross References
OpenTargets
ENSG00000100242
ENSEMBL
ENSP00000385616
,
ENST00000405510
,
ENST00000689035
,
ENST00000405018
,
ENST00000406622
,
ENSP00000508608
,
ENSP00000383992
,
ENSP00000385740
HPA
ENSG00000100242-SUN2
PRO
Q9UH99
Pharos - Targets
Q9UH99
GlyGen
Q9UH99
PDB
6WMD
,
6WME
,
4FI9
,
4DXT
,
4DXS
,
6WMF
,
6WMG
,
4DXR
,
3UNP
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WXH0 SYNE2
1
SYNE2 [nuclear envelope]
(R-HSA-912404)
0.85
11
UniProt:Q8NF91 SYNE1
1
SYNE1 [nuclear envelope]
(R-HSA-912352)
0.807
7
UniProt:P20339 RAB5A
7
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
0.798
6
UniProt:P51148 RAB5C
10
GGC-RAB5C [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871129)
RAB5C [Golgi membrane]
(R-HSA-434334)
RAB5C [cytoplasmic vesicle membrane]
(R-HSA-434198)
RAB5C [early endosome membrane]
(R-HSA-8854157)
GGC-RAB5C [early endosome membrane]
(R-HSA-8875331)
GGC-RAB5C [cytosol]
(R-HSA-8870436)
RAB5C [cytosol]
(R-HSA-8870413)
GGC-RAB5C [macropinosome membrane]
(R-HSA-9837694)
RAB5C [plasma membrane]
(R-HSA-6806265)
RAB5C [azurophil granule membrane]
(R-HSA-6799338)
0.744
5
UniProt:P02545 LMNA
3
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
0.723
5
UniProt:Q8N205 SYNE4
0.71
4
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.683
3
UniProt:Q8N6L0 KASH5
0.683
3
UniProt:P0DTC3 3a
9
O-glycosyl 3a [virion membrane]
(R-COV-9694395)
O-glycosyl 3a [endocytic vesicle membrane]
(R-COV-9694729)
O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694386)
GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694658)
3a [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9694716)
3a [endoplasmic reticulum lumen]
(R-COV-9694584)
O-glycosyl 3a [endolysosome membrane]
(R-COV-9754541)
O-glycosyl 3a [plasma membrane]
(R-COV-9694433)
O-glycosyl 3a [extracellular region]
(R-COV-9694387)
0.659
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.643
4
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.641
4
UniProt:P53618 COPB1
8
COPB1 [endoplasmic reticulum membrane]
(R-HSA-6810955)
COPB1 [Golgi membrane]
(R-HSA-6808735)
COPB1 [transport vesicle]
(R-HSA-6808736)
COPB1 [cytosol]
(R-HSA-199995)
COPB1 [tertiary granule membrane]
(R-HSA-6800175)
COPB1 [secretory granule membrane]
(R-HSA-6800914)
COPB1 [plasma membrane]
(R-HSA-6806431)
COPB1 [ficolin-1-rich granule membrane]
(R-HSA-6800972)
0.564
3
UniProt:Q6ZMZ3 SYNE3
0.558
2
UniProt:Q8IXM6 NRM
0.556
3
UniProt:A5A3E0 POTEF
0.527
2
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.527
3
UniProt:P78356 PIP4K2B
3
p-S326-PIP4K2B [nucleoplasm]
(R-HSA-8877679)
PIP4K2B [nucleoplasm]
(R-HSA-6811503)
PIP4K2B [cytosol]
(R-HSA-1806208)
0.527
3
UniProt:P48426 PIP4K2A
2
PIP4K2A [cytosol]
(R-HSA-1604641)
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
0.527
3
UniProt:P16219 ACADS
1
ACADS [mitochondrial matrix]
(R-HSA-49493)
0.527
2
UniProt:Q9UKA2 FBXL4
1
FBXL4 [cytosol]
(R-HSA-8850899)
0.527
2
UniProt:Q9H9Q2 COPS7B
2
COPS7B [nucleoplasm]
(R-HSA-5697023)
COPS7B [cytosol]
(R-HSA-416966)
0.527
2
UniProt:Q9BTZ2 DHRS4
3
DHRS4 [cytosol]
(R-HSA-9033122)
DHRS4 [peroxisomal matrix]
(R-HSA-9033097)
DHRS4 [endoplasmic reticulum membrane]
(R-HSA-2980897)
0.527
4
UniProt:Q2TAP0 GOG7B
0.527
2
UniProt:Q8WWF5 ZNRF4
0.527
2
UniProt:Q8TBX8 PIP4K2C
2
PIP4K2C [cytosol]
(R-HSA-1604638)
PIP4K2C [nucleoplasm]
(R-HSA-6811499)
0.527
3
UniProt:P50579 METAP2
1
METAP2 [cytosol]
(R-HSA-2534094)
0.527
2
UniProt:P56539 CAV3
1
CAV3 [plasma membrane]
(R-HSA-1368135)
0.527
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.527
4
UniProt:Q8N6G5 CSGALNACT2
1
CSGALNACT2 [Golgi membrane]
(R-HSA-1971506)
0.527
3
UniProt:Q9NZM5 NOP53
0.527
2
UniProt:Q9NWM8 FKBP14 gene
1
FKBP14 [endoplasmic reticulum lumen]
(R-HSA-535607)
0.527
3
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA [cytosol]
(R-HSA-74787)
PIK3CA R38C [cytosol]
(R-HSA-1500691)
PIK3CA R38G [cytosol]
(R-HSA-2395950)
PIK3CA R38S [cytosol]
(R-HSA-2395947)
PIK3CA R38H [cytosol]
(R-HSA-1500718)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
0.527
2
UniProt:Q8NF91-1 SYNE1
0.524
2
UniProt:Q8WXH0-1 SYNE2
0.524
2
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.499
3
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