Formation of axial/lateral elements of Synaptonemal Complex

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R-HSA-912389
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Reaction [omitted]
Species
Homo sapiens
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Axial elements begin assembling as short linear segments along the long axis of the chromosome in leptotene phase. Eventually the short segments will fuse to form the complete axial element along the entire length of the chromosome. After synapsis the axial elements are also known as lateral elements of the synaptonemal complex. Within axial elements the sister chromatids are bound together by meiotic cohesin (Prieto et al. 2004, Garcia-Cruz et al. 2010). The bound chromatids are anchored to a complex containing SYCP2 and SYCP3 via a direct or indirect interaction with cohesin (Garcia-Cruz et al. 2010).

Literature References
PubMed ID Title Journal Year
20634189 Dynamics of cohesin proteins REC8, STAG3, SMC1{beta} and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes

Garcia-Cruz, R, Brieño, MA, Roig, I, Grossmann, M, Velilla, E, Pujol, A, Cabero, L, Pessarrodona, A, Barbero, JL, Garcia Caldés, M

Hum Reprod 2010
15125634 Cohesin component dynamics during meiotic prophase I in mammalian oocytes

Prieto, I, Tease, C, Pezzi, N, Buesa, JM, Ortega, S, Kremer, L, Martinez, A, Martinez-A, C, Hultén, MA, Barbero, JL

Chromosome Res 2004
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