Telomeres cluster at the nuclear membrane

Stable Identifier
R-HSA-912408
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Formation of the telomere bouquet
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with SUN1 and SUN2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin. Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane.

Literature References
PubMed ID Title Journal Year
8794855 Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing

Scherthan, H, Weich, S, Schwegler, H, Heyting, C, Härle, M, Cremer, T

J Cell Biol 1996
Participants
Participant Of
hasEvent
Inferred From
Authored
Reviewed
Created