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TOP3A [nucleoplasm]
Stable Identifier
R-HSA-912452
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA topoisomerase 3-alpha, TOP3A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q5UIP0
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
TOP3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13472 TOP3A
Gene Names
TOP3A, TOP3
Chain
chain:1-1001
Reference Genes
BioGPS Gene:7156 TOP3A
COSMIC (genes):TOP3A TOP3A
CTD Gene:7156 TOP3A
dbSNP Gene:7156 TOP3A
ENSEMBL:ENSG00000177302 TOP3A
ENSEMBL_homo_sapiens_GENE:ENSG00000177302.15 TOP3A
ENSEMBL_homo_sapiens_GENE:ENSG00000284238.2 TOP3A
HGNC:11992 TOP3A
KEGG Gene (Homo sapiens):7156 TOP3A
Monarch:7156 TOP3A
NCBI Gene:7156 TOP3A
OMIM:601243 TOP3A
UCSC:Q13472 TOP3A
Reference Transcript
RefSeq:NM_001320759.1 TOP3A
RefSeq:NM_004618.4 TOP3A
Other Identifiers
1028_at
11728247_a_at
11747776_a_at
16842070
204946_PM_s_at
204946_s_at
214299_PM_at
214299_at
214300_PM_s_at
214300_s_at
3748254
3748256
3748258
3748260
3748261
3748263
3748264
3748265
3748266
3748267
3748268
3748269
3748270
3748271
3748272
3748277
3748278
3748279
3748280
3748282
3748284
3748285
3748286
3748288
3748289
3748290
3748291
3748292
3748293
3748294
3748295
3748298
3748301
3748304
3748306
3748314
3748315
3748316
41004_at
7156
77063_at
8013222
GE59166
GO:0000724
GO:0003677
GO:0003697
GO:0003824
GO:0003916
GO:0003917
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005739
GO:0005759
GO:0006265
GO:0006281
GO:0006310
GO:0007005
GO:0007059
GO:0008270
GO:0016605
GO:0016853
GO:0022414
GO:0031422
GO:0032042
GO:0043226
GO:0046872
GO:0051304
GO:0051321
GO:0071139
GO:0140097
HMNXSV003028500
Hs.91175.1.S1_3p_at
ILMN_1700487
ILMN_2072973
PH_hs_0025390
PH_hs_0033363
TC17001200.hg
U43431_at
g10835217_3p_s_at
Participates
as an input of
Formation of meiotic holliday junction (Homo sapiens)
as an output of
Resolution of meiotic holliday junction (Homo sapiens)
as a component of
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
Inferred To
Top3a [nucleoplasm]
(Rattus norvegicus)
top3a [nucleoplasm]
(Xenopus tropicalis)
TOP3A [nucleoplasm]
(Bos taurus)
TOP3A [nucleoplasm]
(Caenorhabditis elegans)
TOP3A [nucleoplasm]
(Canis familiaris)
TOP3A [nucleoplasm]
(Gallus gallus)
TOP3A [nucleoplasm]
(Mus musculus)
TOP3A [nucleoplasm]
(Sus scrofa)
top3 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001307688.1
,
NP_004609.1
OpenTargets
ENSG00000177302
IntEnz
5.6.2.1
GeneCards
Q13472
HPA
ENSG00000177302-TOP3A
Ensembl
ENST00000640743
,
ENSP00000462790
,
ENSP00000321636
,
ENST00000321105
,
ENSP00000491260
,
ENSG00000177302
,
ENST00000580095
,
ENSP00000491689
,
ENST00000639065
,
ENSG00000284238
PRO
Q13472
Pharos - Targets
Q13472
Orphanet
27334
PDB
4CHT
,
4CGY
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H9A7 RMI1
1
RMI1 [nucleoplasm]
(R-HSA-5685949)
0.912
10
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.853
9
UniProt:Q96E14-1 RMI2
0.527
2
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.463
4
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.462
3
UniProt:Q14159 SPIDR
1
SPIDR [nucleoplasm]
(R-HSA-5686408)
0.462
2
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