BRCA1 is recruited to unsynapsed regions

Stable Identifier
R-HSA-912467
Type
Reaction [binding]
Species
Homo sapiens
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Unsynapsed regions of chromosomes are silenced during pachytene phase by a process called Meiotic Silencing of Unsynapsed Chromatin (MSUC) and, in the case of the X and Y chromosomes, Meiotic Sex Chromosome Inactivation (MSCI). Unsynapsed meiotic chromatin recruits BRCA1 (Scully et al. 1997, Garcia-Cruz et al. 2009). In mouse, the recruitment requires SYCP3 of axial elements of the synaptonemal complex, which may remain exposed in unsynapsed regions.

Literature References
PubMed ID Title Journal Year
19146767 ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes

Garcia-Cruz, R, Roig, I, Robles, P, Scherthan, H, Garcia Cald├ęs, M

Reprod Biomed Online 2009
9008167 Association of BRCA1 with Rad51 in mitotic and meiotic cells

Scully, R, Chen, J, Plug, A, Xiao, Y, Weaver, D, Feunteun, J, Ashley, T, Livingston, DM

Cell 1997
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