ATR phosphorylates Histone H2A.X at unsynapsed regions

Stable Identifier
R-HSA-912470
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The ATR kinase phosphorylates histone H2A.X at serine 139 (Ward and Chen 2001, Garcia-Cruz et al. 2009).

Literature References
PubMed ID Title Journal Year
19146767 ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes

Garcia-Cruz, R, Roig, I, Robles, P, Scherthan, H, Garcia Cald├ęs, M

Reprod Biomed Online 2009
11673449 Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, IM, Chen, J

J Biol Chem 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created