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HSPA2 [nucleoplasm]
Stable Identifier
R-HSA-912480
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Heat shock-related 70 kDa protein 2, HSP72_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q99615 DNAJC7
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Synapsis (Homo sapiens)
HSPA2 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Synapsis (Homo sapiens)
HSPA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54652 HSPA2
Gene Names
HSPA2
Chain
chain:1-639
Reference Genes
BioGPS Gene:3306 HSPA2
COSMIC (genes):HSPA2 HSPA2
CTD Gene:3306 HSPA2
dbSNP Gene:3306 HSPA2
ENSEMBL:ENSG00000126803 HSPA2
HGNC:5235 HSPA2
KEGG:hsa:3306 HSPA2
Monarch:3306 HSPA2
NCBI Gene:3306 HSPA2
OMIM:140560 HSPA2
UCSC:P54652 HSPA2
Reference Transcript
RefSeq:NM_001387931.1 HSPA2
RefSeq:NM_021979.3 HSPA2
Other Identifiers
11724723_a_at
16785379
211538_PM_s_at
211538_s_at
2363790
3306
3540137
3540138
3540139
3540140
3540141
3540142
3540143
3540144
3540145
3540146
3540147
3540148
3540156
3540157
3540158
36925_at
645_at
7975076
A_14_P200378
A_23_P88303
GE59248
GO:0000795
GO:0001673
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0006457
GO:0006986
GO:0007140
GO:0007141
GO:0007283
GO:0007286
GO:0008092
GO:0008289
GO:0009408
GO:0009409
GO:0009986
GO:0010971
GO:0016020
GO:0016787
GO:0016887
GO:0019899
GO:0022414
GO:0030154
GO:0031072
GO:0036128
GO:0042026
GO:0043226
GO:0044183
GO:0048156
GO:0048856
GO:0051082
GO:0051085
GO:0051087
GO:0051861
GO:0070062
GO:0070194
GO:0072562
GO:0072687
GO:0090084
GO:0097718
GO:0140013
GO:0140657
GO:0140662
HMNXSV003027503
ILMN_1766499
ILMN_2153916
L26336_at
PH_hs_0020027
TC14000391.hg
g4204879_3p_a_at
Participates
as a component of
HSPA2:ADP [nucleoplasm] (Homo sapiens)
HSPA2:ATP [nucleoplasm] (Homo sapiens)
Synaptonemal Complex [nucleoplasm] (Homo sapiens)
as a candidate of
HSPA (HSP70) proteins [nucleoplasm] (Homo sapiens)
as an input of
Synapsis (Homo sapiens)
Other forms of this molecule
HSPA2 [cytosol]
Inferred To
Hsp70Ab [nucleoplasm]
(Drosophila melanogaster)
Homologues of HSPA2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of HSPA2 [nucleoplasm]
(Drosophila melanogaster)
Homologues of HSPA2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of HSPA2 [nucleoplasm]
(Schizosaccharomyces pombe)
Hsc70-2 [nucleoplasm]
(Drosophila melanogaster)
SSB2 [nucleoplasm]
(Saccharomyces cerevisiae)
SSA4 [nucleoplasm]
(Saccharomyces cerevisiae)
Hsp70Bc [nucleoplasm]
(Drosophila melanogaster)
HSPA2 [nucleoplasm]
(Bos taurus)
HSPA2 [nucleoplasm]
(Canis familiaris)
HSPA2 [nucleoplasm]
(Dictyostelium discoideum)
hspa2 [nucleoplasm]
(Xenopus tropicalis)
Hsp70Bb [nucleoplasm]
(Drosophila melanogaster)
ssa1 [nucleoplasm]
(Schizosaccharomyces pombe)
Hspa2 [nucleoplasm]
(Mus musculus)
Hspa2 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG7182 [nucleoplasm]
(Drosophila melanogaster)
Hsp70Bbb [nucleoplasm]
(Drosophila melanogaster)
SSA2 [nucleoplasm]
(Saccharomyces cerevisiae)
hspa8 [nucleoplasm]
(Danio rerio)
Hsp68 [nucleoplasm]
(Drosophila melanogaster)
Hsp70Aa [nucleoplasm]
(Drosophila melanogaster)
ssa2 [nucleoplasm]
(Schizosaccharomyces pombe)
SSB1 [nucleoplasm]
(Saccharomyces cerevisiae)
Hsc70-1 [nucleoplasm]
(Drosophila melanogaster)
SSA3 [nucleoplasm]
(Saccharomyces cerevisiae)
Hsc70-4 [nucleoplasm]
(Drosophila melanogaster)
sks2 [nucleoplasm]
(Schizosaccharomyces pombe)
hsp-1 [nucleoplasm]
(Caenorhabditis elegans)
Hsp70Ba [nucleoplasm]
(Drosophila melanogaster)
hspB [nucleoplasm]
(Dictyostelium discoideum)
hspE-1; hspE-2 [nucleoplasm]
(Dictyostelium discoideum)
SSA1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_068814.2
,
NP_001374860.1
Guide to Pharmacology - Targets
2541
OpenTargets
ENSG00000126803
ENSEMBL
ENSP00000247207
,
ENST00000247207
,
ENSG00000126803
,
ENST00000394709
,
ENSP00000378199
GeneCards
HSPA2
HPA
ENSG00000126803-HSPA2
PRO
P54652
Pharos - Targets
P54652
GlyGen
P54652
PDB
4FSV
,
5FPD
,
5FPE
,
3I33
,
5FPM
,
5FPN
Interactors (84)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZL4 HPBP1
0.917
10
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.745
7
UniProt:O95429 BAG4
3
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.703
5
UniProt:Q03933 HSF2
0.669
3
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.666
4
UniProt:Q9NSA1 FGF21
2
FGF21 [cytosol]
(R-HSA-6784692)
FGF21 [extracellular region]
(R-HSA-189909)
0.61
4
UniProt:Q58EX7-2 Q58EX72
0.556
3
UniProt:O60636 TSN2
0.556
3
UniProt:Q9NUC0 SRTD4
0.556
3
UniProt:Q8WUX9 CHMP7
2
CHMP7 [cytosol]
(R-HSA-917703)
CHMP7 [endosome membrane]
(R-HSA-9631168)
0.556
3
IntAct:EBI-25852558 CCSB
0.556
3
UniProt:Q92782-2 Q927822
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.556
3
UniProt:Q9NX94 WBP1L
0.556
3
UniProt:Q8WUU4 ZN296
0.556
3
UniProt:Q9BRR0 ZKSCAN3
1
ZKSCAN3 [nucleoplasm]
(R-HSA-1027422)
0.556
3
UniProt:Q9UHI5 SLC7A8
1
SLC7A8 [plasma membrane]
(R-HSA-352156)
0.556
3
UniProt:Q96FT7-4 ASIC4
0.556
3
UniProt:P49459 UBE2A
3
UBE2A [cytosol]
(R-HSA-947617)
Ub-C88-UBE2A [nucleoplasm]
(R-HSA-8864186)
UBE2A [nucleoplasm]
(R-HSA-8852048)
0.556
3
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.556
3
UniProt:O15534 PER1
4
PER1 [cytosol]
(R-HSA-400373)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
p-S-PER1 [cytosol]
(R-HSA-400310)
K48polyUb-K,p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:Q6DHV7-2 Q6DHV72
0.556
3
UniProt:Q92615 LAR4B
0.556
3
UniProt:P79522 PRR3
0.556
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:Q9H1D9 POLR3F
2
POLR3F [cytosol]
(R-HSA-1964434)
POLR3F [nucleoplasm]
(R-HSA-83708)
0.556
3
UniProt:Q96DX5 ASB9
1
ASB9 [cytosol]
(R-HSA-975424)
0.556
3
UniProt:Q13562 NEUROD1
1
NEUROD1 [nucleoplasm]
(R-HSA-186689)
0.556
3
UniProt:Q96MA6 AK8
1
AK8 [cytosol]
(R-HSA-6788788)
0.556
3
UniProt:P05455 SSB
1
SSB [nucleoplasm]
(R-HSA-58418)
0.556
3
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.556
3
UniProt:Q96EY1-3 DNAJA3
0.556
3
UniProt:Q496A3 SPAS1
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q7Z6I5 SPT12
0.556
3
UniProt:P15407 FOSL1
1
FOSL1 [nucleoplasm]
(R-HSA-9620405)
0.556
3
UniProt:Q06547-3 GABPB1
1
NRF2 gamma-1 subunit [nucleoplasm]
(R-HSA-1592216)
0.556
3
UniProt:Q9BYN7-2 ZNF341
0.556
3
UniProt:P30301 MIP
1
MIP [plasma membrane]
(R-HSA-432026)
0.556
3
UniProt:Q06547-2 GABPB1
1
NRF2 beta-2 subunit [nucleoplasm]
(R-HSA-1592200)
0.556
3
UniProt:Q3KNS6-3 Q3KNS63
0.556
3
IntAct:EBI-25835866 CCSB
0.556
3
UniProt:Q6P597 KLC3
1
KLC3 [cytosol]
(R-HSA-983232)
0.556
3
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.556
3
UniProt:Q14181 POLA2
1
POLA2 [nucleoplasm]
(R-HSA-68493)
0.556
3
UniProt:Q8N0U2 TMM61
0.556
3
UniProt:Q6GQQ9-2 Q6GQQ92
0.556
3
UniProt:Q66PJ3-4 ARL6IP4
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q15973 ZNF124
1
ZNF124 [nucleoplasm]
(R-HSA-975017)
0.556
3
UniProt:Q9Y4F5-3 CEP170B
0.556
3
UniProt:Q9HD47-3 RANGRF
0.556
3
UniProt:Q53R41 FAKD1
0.556
3
UniProt:Q8TBE0 BAHD1
0.556
3
UniProt:Q5SXH7-1 PLEKHS1
0.556
3
IntAct:EBI-25835796 CCSB
0.556
3
UniProt:Q8N5Z5 KCD17
0.556
3
UniProt:Q8N2H9-4 PELI3
0.556
3
UniProt:Q9NNX6-10 CD209
0.556
3
UniProt:Q7Z7C8-2 TAF8
0.556
3
UniProt:O95149 SNUPN
1
SNUPN [cytosol]
(R-HSA-191857)
0.527
2
UniProt:Q7Z5L9 I2BP2
0.527
2
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.527
2
UniProt:Q15555 MARE2
0.527
2
UniProt:Q969K3 RNF34
2
RNF34 [nucleoplasm]
(R-HSA-6804442)
RNF34 [cytosol]
(R-HSA-975998)
0.527
2
UniProt:Q2M3G4 SHRM1
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
4
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:Q99615 DNAJC7
2
DNAJC7 [nucleoplasm]
(R-HSA-5255408)
DNAJC7 [cytosol]
(R-HSA-5252099)
0.527
2
UniProt:P34932 HSPA4
2
HSPA4 [cytosol]
(R-HSA-5251946)
HSPA4 [nucleoplasm]
(R-HSA-5251998)
0.527
2
UniProt:Q5JPI3 CC038
0.527
3
UniProt:P50895 BCAM
0.527
2
UniProt:Q9UNN5 FAF1
0.527
2
UniProt:Q14249 NUCG
0.527
2
UniProt:Q8N239 KLH34
0.527
2
UniProt:O75165 DNAJC13
3
DNAJC13 [secretory granule membrane]
(R-HSA-6800951)
DNAJC13 [plasma membrane]
(R-HSA-6806255)
DNAJC13 [azurophil granule membrane]
(R-HSA-6799140)
0.527
2
UniProt:Q9NVT9 ARMC1
0.527
2
UniProt:Q6UXT9 ABH15
0.527
3
UniProt:Q8IWD4 CC117
0.527
3
UniProt:P46937 YAP1
8
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
0.527
2
UniProt:Q00613 HSF1
11
HSF1 [cytosol]
(R-HSA-3371452)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
HSF1 [nucleoplasm]
(R-HSA-5082385)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
0.527
2
UniProt:Q96BE0 Q96BE0
0.499
2
UniProt:O77932 DXO
1
DXO [nucleoplasm]
(R-HSA-9935314)
0.488
2
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