SHC1 mediates cytokine-induced phosphorylation of GAB2

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Locations in the PathwayBrowser

Binding of Gab2 to tyrosine phosphorylated Shc promotes the phosphorylation of Gab2 by an unknown kinase. Gab2 becomes tyrosine phosphorylated in response to IL-2 (Brockdorff et al. 2001) and IL-3 (Gu et al. 1998). Chimeric receptors were used to demonstrate that Shc is sufficient for Gab2 tyrosine phosphorylation. In response to IL-3, Grb2 was also required, reflecting that Gab2 is recruited to the activated cytokine receptor complex as a complex of Gab2:Grb2 (Gu et al. 2000).

Literature References
PubMed ID Title Journal Year
11340297 Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a

Brockdorff, JL, Gu, H, Mustelin, T, Kaltoft, K, Geisler, C, Röpke, C, Ødum, N

Exp Clin Immunogenet 2001
10982827 New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

Gu, H, Maeda, H, Moon, JJ, Lord, JD, Yoakim, M, Nelson, BH, Neel, BG

Mol Cell Biol 2000
Participant Of
Orthologous Events