SHC1 mediates cytokine-induced phosphorylation of GAB2

Stable Identifier
R-HSA-912527
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding of Gab2 to tyrosine phosphorylated Shc promotes the phosphorylation of Gab2 by an unknown kinase. Gab2 becomes tyrosine phosphorylated in response to IL-2 (Brockdorff et al. 2001) and IL-3 (Gu et al. 1998). Chimeric receptors were used to demonstrate that Shc is sufficient for Gab2 tyrosine phosphorylation. In response to IL-3, Grb2 was also required, reflecting that Gab2 is recruited to the activated cytokine receptor complex as a complex of Gab2:Grb2 (Gu et al. 2000).

Literature References
PubMed ID Title Journal Year
11340297 Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a

Brockdorff, JL, Gu, H, Mustelin, T, Kaltoft, K, Geisler, C, Röpke, C, Ødum, N

Exp Clin Immunogenet 2001
10982827 New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

Gu, H, Maeda, H, Moon, JJ, Lord, JD, Yoakim, M, Nelson, BH, Neel, BG

Mol Cell Biol 2000
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