Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ATP6V1B1 [cytosol]
Stable Identifier
R-HSA-912604
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B exchanges GDP for GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
RRAGC,D exchanges GTP for GDP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
RRAGC,D hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
mTORC1 binds RHEB:GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
V-ATPase [phagocytic vesicle membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
Endosome acidification (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1B trimer [cytosol] (Homo sapiens)
ATP6V1B [cytosol] (Homo sapiens)
ATP6V1B1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15313 ATP6V1B1
Gene Names
ATP6V1B1, ATP6B1, VATB, VPP3
Chain
chain:1-513
Reference Genes
BioGPS Gene:525 ATP6V1B1
COSMIC (genes):ATP6V1B1 ATP6V1B1
CTD Gene:525 ATP6V1B1
dbSNP Gene:525 ATP6V1B1
ENSEMBL:ENSG00000116039 ATP6V1B1
HGNC:853 ATP6V1B1
KEGG:hsa:525 ATP6V1B1
Monarch:525 ATP6V1B1
NCBI Gene:525 ATP6V1B1
OMIM:192132 ATP6V1B1
UCSC:P15313 ATP6V1B1
Reference Transcript
RefSeq:NM_001692.3 ATP6V1B1
Other Identifiers
11718919_a_at
1554847_PM_at
1554847_at
16881199
205473_3p_at
205473_PM_at
205473_at
2487921
2487922
2487923
2487932
2487933
2487934
2487942
2487943
2487945
2487946
2487947
2487948
2487949
2487950
2487951
2487952
2487953
2487954
2487955
2487956
2487958
2487959
2487960
2487961
2487962
32959_at
46588_f_at
525
8042537
8042556
A_14_P116717
A_23_P142815
A_24_P145249
GE57888
GO:0000221
GO:0001503
GO:0003014
GO:0003091
GO:0003096
GO:0005215
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005902
GO:0006629
GO:0006693
GO:0006811
GO:0006885
GO:0007035
GO:0007605
GO:0010468
GO:0015078
GO:0016020
GO:0016241
GO:0016323
GO:0016324
GO:0016328
GO:0016469
GO:0016471
GO:0030534
GO:0031090
GO:0033180
GO:0035812
GO:0042048
GO:0042472
GO:0043226
GO:0044877
GO:0045851
GO:0046034
GO:0046961
GO:0050877
GO:0055064
GO:0055074
GO:0055075
GO:0055085
GO:0055086
GO:0065003
GO:0070062
GO:0070072
GO:0097254
GO:0097401
GO:0098850
GO:0140657
GO:1901135
GO:1902600
HMNXSV003008904
Hs2.385681.1.S1_3p_at
ILMN_1812073
M25809_at
PH_hs_0003994
TC02000423.hg
g4502308_3p_s_at
Participates
as a member of
ATP6V1B [cytosol] (Homo sapiens)
Inferred To
Atp6v1b1 [cytosol]
(Rattus norvegicus)
vatB [cytosol]
(Dictyostelium discoideum)
ATP6V1B1 [cytosol]
(Bos taurus)
ATP6V1B1 [cytosol]
(Caenorhabditis elegans)
ATP6V1B1 [cytosol]
(Canis familiaris)
ATP6V1B1 [cytosol]
(Drosophila melanogaster)
ATP6V1B1 [cytosol]
(Mus musculus)
ATP6V1B1 [cytosol]
(Plasmodium falciparum)
ATP6V1B1 [cytosol]
(Saccharomyces cerevisiae)
ATP6V1B1 [cytosol]
(Schizosaccharomyces pombe)
ATP6V1B1 [cytosol]
(Sus scrofa)
atp6v1b1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001683.2
Guide to Pharmacology - Targets
811
ENSEMBL
ENST00000234396
,
ENSP00000234396
OpenTargets
ENSG00000116039
HPA
ENSG00000116039-ATP6V1B1
ZINC target
P15313
PRO
P15313
Pharos - Targets
P15313
Orphanet
ATP6V1B1
HMDB Protein
HMDBP01294
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text