Reactome | ATP6V0A4 [endosome membrane]

ATP6V0A4 [endosome membrane]

Stable Identifier

R-HSA-912605

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - ATP6AP1 binds V-ATPase (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0A [endosome membrane] (Homo sapiens)
        
        ATP6V0A4 [endosome membrane] (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0A [endosome membrane] (Homo sapiens)
        
        ATP6V0A4 [endosome membrane] (Homo sapiens)
      - Endosome acidification (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0A [endosome membrane] (Homo sapiens)
        
        ATP6V0A4 [endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HBG4 ATP6V0A4

Gene Names

ATP6V0A4, ATP6N1B, ATP6N2

Chain

chain:1-840

Reference Genes

BioGPS Gene:50617 ATP6V0A4

COSMIC (genes):ATP6V0A4 ATP6V0A4

CTD Gene:50617 ATP6V0A4

dbSNP Gene:50617 ATP6V0A4

ENSEMBL:ENSG00000105929 ATP6V0A4

ENSEMBL_homo_sapiens_GENE:ENSG00000105929.16 ATP6V0A4

HGNC:866 ATP6V0A4

KEGG Gene (Homo sapiens):50617 ATP6V0A4

Monarch:50617 ATP6V0A4

NCBI Gene:50617 ATP6V0A4

OMIM:605239 ATP6V0A4

UCSC:Q9HBG4 ATP6V0A4

Reference Transcript

Other Identifiers

11728159_a_at

11738077_a_at

17063366

220197_PM_at

220197_at

3075382

3075383

3075384

3075385

3075389

3075390

3075392

3075393

3075394

3075398

3075399

3075402

3075403

3075404

3075406

3075407

3075409

3075412

3075413

3075414

3075416

3075417

3075418

3075419

3075422

3075424

3075425

3075427

3075428

49808_at

50617

8143221

A_23_P215111

GE82549

GO:0000220

GO:0001503

GO:0003014

GO:0005215

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0005903

GO:0006811

GO:0006885

GO:0007035

GO:0007605

GO:0010008

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0016471

GO:0030670

GO:0030672

GO:0031410

GO:0031526

GO:0033176

GO:0033179

GO:0043226

GO:0045177

GO:0046961

GO:0050877

GO:0051117

GO:0051452

GO:0055085

GO:0070062

GO:0097254

GO:0097401

GO:0140657

GO:1902600

HMNXSV003018361

ILMN_1678186

ILMN_1721788

ILMN_1812896

ILMN_2394287

PH_hs_0005492

TC07001906.hg

g10190665_3p_at

Participates

as a member of

ATP6V0A [endosome membrane] (Homo sapiens)

Other forms of this molecule

ATP6V0A4 [phagocytic vesicle membrane]

Inferred To

Homologues of ATP6V0A4 [endosome membrane] (Caenorhabditis elegans)

Homologues of ATP6V0A4 [endosome membrane] (Drosophila melanogaster)

Homologues of ATP6V0A4 [endosome membrane] (Saccharomyces cerevisiae)

unc-32 [endosome membrane] (Caenorhabditis elegans)

Atp6v0a4 [endosome membrane] (Mus musculus)

Atp6v0a4 [endosome membrane] (Rattus norvegicus)

Vha100-3 [endosome membrane] (Drosophila melanogaster)

atp6v0a4 [endosome membrane] (Xenopus tropicalis)

Vha100-2 [endosome membrane] (Drosophila melanogaster)

ATP6V0A4 [endosome membrane] (Bos taurus)

ATP6V0A4 [endosome membrane] (Canis familiaris)

ATP6V0A4 [endosome membrane] (Gallus gallus)

ATP6V0A4 [endosome membrane] (Plasmodium falciparum)

vatM [endosome membrane] (Dictyostelium discoideum)

Vha100-1 [endosome membrane] (Drosophila melanogaster)

Vha100-5 [endosome membrane] (Drosophila melanogaster)

STV1 [endosome membrane] (Saccharomyces cerevisiae)

vha-7 [endosome membrane] (Caenorhabditis elegans)

vph1 [endosome membrane] (Schizosaccharomyces pombe)

Vha100-4 [endosome membrane] (Drosophila melanogaster)

vha-5 [endosome membrane] (Caenorhabditis elegans)

VPH1 [endosome membrane] (Saccharomyces cerevisiae)

vha-6 [endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_065683.2, XP_005250450.1, XP_005250451.1, NP_570856.2, NP_570855.2

Guide to Pharmacology - Targets

826

OpenTargets

ENSG00000105929

GeneCards

Q9HBG4

HPA

ENSG00000105929-ATP6V0A4

Ensembl

ENST00000645515, ENSP00000308122, ENSP00000496421, ENST00000353492, ENST00000310018, ENSP00000376774, ENSP00000253856, ENST00000393054, ENSG00000105929

PRO

Q9HBG4

Pharos - Targets

Q9HBG4

Orphanet

15327

HMDB Protein

HMDBP01307

PDB

7UNF

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) APOE-4 [extracellular region] (R-HSA-9711070) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.556	3