Inhibition of JAK kinase activity by SOCS1/3

Stable Identifier
R-HSA-912680
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SOCS1/3 are the major negative regulators of IFNA/B signaling. They inhibit JAKs catalytic activity directly through their kinase inhibitory region (KIR) and turn off downstream IFNA/B signaling. SOCS1 may also prevent IFN signaling by targeting the signaling machinery to ubiquitin-proteasomal degradation pathway.

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