Reactome: A Curated Pathway Database

UBP43 binds IFNAR2 and prevents JAK1 interaction

Stable Identifier
R-HSA-912685
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

UBP43, a type I IFN-inducible cysteine protease acts as a negative regulator of type I IFN signaling. UBP43 binds directly to IFNAR2 and blocks JAK-receptor interaction leading to inhibition of downstream phosphorylation and other signaling events.

Literature References
Participants
Participant Of
Orthologous Events