UBP43 binds IFNAR2 and prevents JAK1 interaction

Stable Identifier
R-HSA-912685
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

UBP43, a type I IFN-inducible cysteine protease acts as a negative regulator of type I IFN signaling. UBP43 binds directly to IFNAR2 and blocks JAK-receptor interaction leading to inhibition of downstream phosphorylation and other signaling events.

Literature References
PubMed ID Title Journal Year
16710296 UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

Malakhova, OA, Kim, KI, Luo, JK, Zou, W, Kumar, KG, Fuchs, SY, Shuai, K, Zhang, DE

EMBO J 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed