Regulation of IFNA signaling

Stable Identifier
R-HSA-912694
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Pathway
Species
Homo sapiens
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There are several proteins and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling. These mechanisms can effect every step of the IFNA/B cascade. Dephosphorylation of JAK and STAT by SHP protein phosphatases, inhibition of STAT function in the nucleus by protein inhibitors of activated STATs (PIAS) proteins, inhibition of tyrosine kinase activity of JAKs by SOCS as well as inhibition of JAK and IFNAR2 interaction by UBP43 are few of the negative regulation mechanisms in controling type I IFN signaling.

Literature References
PubMed ID Title Journal Year
16710296 UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

Malakhova, OA, Kim, KI, Luo, JK, Zou, W, Kumar, KG, Fuchs, SY, Shuai, K, Zhang, DE

EMBO J 2006
10526574 Negative regulators of cytokine signal transduction

Hilton, DJ

Cell Mol Life Sci 1999
16311601 Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

Fenner, JE, Starr, R, Cornish, AL, Zhang, JG, Metcalf, D, Schreiber, RD, Sheehan, K, Hilton, DJ, Alexander, WS, Hertzog, PJ

Nat Immunol 2006
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Orthologous Events
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