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K48-Ub [cytosol]
Stable Identifier
R-HSA-912722
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K48-ubiquitin
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 9b recruits ITCH to MAVS (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
SIAH1, SIAH2 ubiquitinate SNCAIP (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
PARK2 autoubiquitinates (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP11 deubiquitinates NFKBIA (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP25 deubiquitinates DDX58 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP5 cleaves polyubiquitin (Homo sapiens)
USP5:PolyUb [cytosol] (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
USP8 deubiquitinates RNF128 (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
USP17L2 deubiquitinates RCE1 (Homo sapiens)
PolyUb [cytosol] (Homo sapiens)
K48polyUb [cytosol] (Homo sapiens)
K48-Ub [cytosol] (Homo sapiens)
General
The most studied polyubiquitin chains - lysine48-linked - target proteins for destruction
Participants
members
Ub-48-RPS27A(1-76) [cytosol]
(Homo sapiens)
Ub-48-UBA52(1-76) [cytosol]
(Homo sapiens)
Ub-48-UBB(1-76) [cytosol]
(Homo sapiens)
Ub-124-UBB(77-152) [cytosol]
(Homo sapiens)
Ub-200-UBB(153-228) [cytosol]
(Homo sapiens)
Ub-48-UBC(1-76) [cytosol]
(Homo sapiens)
Ub-124-UBC(77-152) [cytosol]
(Homo sapiens)
Ub-200-UBC(153-228) [cytosol]
(Homo sapiens)
Ub-276-UBC(229-304) [cytosol]
(Homo sapiens)
Ub-352-UBC(305-380) [cytosol]
(Homo sapiens)
Ub-428-UBC(381-456) [cytosol]
(Homo sapiens)
Ub-504-UBC(457-532) [cytosol]
(Homo sapiens)
Ub-580-UBC(533-608) [cytosol]
(Homo sapiens)
Ub-656-UBC(609-684) [cytosol]
(Homo sapiens)
Participates
as an input of
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
as a repeated unit of
K48polyUb [cytosol] (Homo sapiens)
K48-linked polyubiquitin chain [cytosol] (Homo sapiens)
Inferred To
ubi4 [cytosol]
(Schizosaccharomyces pombe)
UBI4 [cytosol]
(Saccharomyces cerevisiae)
K48-Ub [cytosol]
(Bos taurus)
K48-Ub [cytosol]
(Caenorhabditis elegans)
K48-Ub [cytosol]
(Canis familiaris)
K48-Ub [cytosol]
(Danio rerio)
K48-Ub [cytosol]
(Dictyostelium discoideum)
K48-Ub [cytosol]
(Drosophila melanogaster)
K48-Ub [cytosol]
(Gallus gallus)
K48-Ub [cytosol]
(Mus musculus)
K48-Ub [cytosol]
(Plasmodium falciparum)
K48-Ub [cytosol]
(Rattus norvegicus)
K48-Ub [cytosol]
(Sus scrofa)
K48-Ub [cytosol]
(Xenopus tropicalis)
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