CBL binds B-cell linker protein

Stable Identifier
R-HSA-912724
Type
Reaction [binding]
Species
Homo sapiens
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Cbl binds B-cell linker protein, a molecular scaffold bridging Syk to downstream signaling pathways by recruiting signaling molecules, such as Btk, phospholipase C gamma 2, Vav, and Grb2 to the cell membrane to form a signalosome complex. Cbl is believed to negatively regulate signaling from this complex. Consistent with this, Cbl inactivation reverses a number of critical defects in early B cell differentiation seen in BLNK-deficient mice (Song et al. 2007).

Literature References
PubMed ID Title Journal Year
17202354 Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway

Song, H, Zhang, J, Chiang, YJ, Siraganian, RP, Hodes, RJ

J Immunol 2007
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