CBL binds VAV

Stable Identifier
R-HSA-912727
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cbl and Vav interact in thymocytes and peripheral T cells (Marengere et al. 1997). Cbl phosphorylated at Y700 binds Vav1 in 293T cells, leading to Vav ubiquitinylation and proteolytic degradation.

Literature References
PubMed ID Title Journal Year
12881521 Cbl-mediated ubiquitinylation and negative regulation of Vav

Miura-Shimura, Y, Duan, L, Rao, NL, Reddi, AL, Shimura, H, Rottapel, R, Druker, BJ, Tsygankov, A, Band, V, Band, H

J Biol Chem 2003
9200440 Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells

Marengère, LE, Mirtsos, C, Kozieradzki, I, Veillette, A, Mak, TW, Penninger, JM

J Immunol 1997
Participants
Participant Of
Orthologous Events
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