CBL binds VAV

Stable Identifier
R-HSA-912727
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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CBL binds VAV
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Cbl and Vav interact in thymocytes and peripheral T cells (Marengere et al. 1997). Cbl phosphorylated at Y700 binds Vav1 in 293T cells, leading to Vav ubiquitinylation and proteolytic degradation.

Literature References
PubMed ID Title Journal Year
12881521 Cbl-mediated ubiquitinylation and negative regulation of Vav

Miura-Shimura, Y, Duan, L, Rao, NL, Reddi, AL, Shimura, H, Rottapel, R, Druker, BJ, Tsygankov, A, Band, V, Band, H

J Biol Chem 2003
9200440 Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells

Marengère, LE, Mirtsos, C, Kozieradzki, I, Veillette, A, Mak, TW, Penninger, JM

J Immunol 1997
Participants
Input
Output
Participant Of
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Orthologous Events
CBL binds VAV (Caenorhabditis elegans)
CBL binds VAV (Canis familiaris)
CBL binds VAV (Drosophila melanogaster)
CBL binds VAV (Mus musculus)
CBL binds VAV (Rattus norvegicus)
CBL binds VAV (Sus scrofa)
CBL binds VAV (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Lopez, AF  (2010-09-06)
Hercus, TR  (2010-09-06)
Created
Jupe, S  (2010-07-13)