Reactome | p-S585-IL3RB binds 14-3-3 proteins

p-S585-IL3RB binds 14-3-3 proteins

Stable Identifier

R-HSA-912757

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Summation

The common beta chain (Bc), binds 14-3-3 zeta at a site that requires phosphorylation of Serine 585 (Stomski et al. 1999). Bc modifications that prevent Ser-585 phosphorylation do not recruit 14-3-3 zeta (Guthridge et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10477722	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF	Blood	1999

Participants

Input

Output

High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

Interleukin-3, Interleukin-5 and GM-CSF signaling

Orthologous Events

p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)

p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)

p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)

p-S585-IL3RB binds 14-3-3 proteins (Taeniopygia guttata)

p-S585-IL3RB binds 14-3-3 proteins (Xenopus tropicalis)