CBL binds CRK

Stable Identifier
R-HSA-912790
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The Crk adapter protein family is comprised of Crk-I and Crk-II, alternatively spliced products of a single gene with differing biological functions, and Crk-L, a distinct Crk-like gene product. Cbl is the dominant phosphoprotein associated with Crk in activated lymphocytes. In vitro binding indicates that the Crk SH2 domain binds Y774 of Cbl (Reedquist et al. 1996), leaving the SH3 domain of Crk free to interact with other SH3 domain-associated proteins.

Literature References
PubMed ID Title Journal Year
8649859 The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain

Andoniou, CE, Thien, CB, Langdon, WY

Oncogene 1996
8626543 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

Reedquist, KA, Fukazawa, T, Panchamoorthy, G, Langdon, WY, Shoelson, SE, Druker, BJ, Band, H

J Biol Chem 1996
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