GM-CSF receptor alpha subunit binds GM-CSF

Stable Identifier
R-HSA-913360
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The GM-CSF receptor alpha subunit has a single transmembrane domain, a glycosylated extracellular domain and a short (54 amino acids) cytoplasmic tail, containing no tyrosine kinase domain (Gearing et al. 1989). It binds GM-CSF with a relatively low affinity, and is not capable of signaling. The cytoplasmic domain of the alpha chain appears to be critical for GM-CSF signaling (Matsuguchi et al. 1997).

Literature References
PubMed ID Title Journal Year
2555171 Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor

Gearing, DP, King, JA, Gough, NM, Nicola, NA

EMBO J 1989
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