IL3RB is phosphorylated on Ser-585

Stable Identifier
R-HSA-913451
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GM-CSF and IL-3 application lead to Ser-585 phosphorylation of the Common beta chain (Bc) shared with the IL-3 and IL-5 receptors (Stomski et al. 1999, Guthridge et al. 2000). PKA was identified as capable of phosphorylating Bc at S585 (Guthridge et al. 2000).

Literature References
PubMed ID Title Journal Year
10949031 Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival

Guthridge, MA, Stomski, FC, Barry, EF, Winnall, W, Woodcock, JM, McClure, BJ, Dottore, M, Berndt, MC, Lopez, AF

Mol Cell 2000
10477722 Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF

Stomski, FC, Dottore, M, Winnall, W, Guthridge, MA, Woodcock, J, Bagley, CJ, Thomas, DT, Andrews, RK, Berndt, MC, Lopez, AF

Blood 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cAMP-dependent protein kinase activity of PRKACA [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed