Translocation of p-STAT1:p-STAT1 dimer to nucleus

Stable Identifier
R-HSA-913529
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
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Translocation of p-STAT1:p-STAT1 dimer to nucleus
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IFNA-activated-factor (AAF) translocates to nucleus and then promotes the expression of a distinct set of gamma activated sequence (GAS)-driven genes like IRF1. IRF1, in turn, induces the transcription of ISG15, ISG54 and IFI6 genes. This second pathway of STAT1 homodimer formation is primarily activated by IFNG and is likely to account for some of the functional overlap between type I and type II IFNs.
Literature References
PubMed ID Title Journal Year
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Cowburn, D, Horvath, CM, Huang, LH, Darnell JE, Jr, Qureshi, SA, Shuai, K

Cell 1994
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Orthologous Events
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Caenorhabditis elegans)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Canis familiaris)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Drosophila melanogaster)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Gallus gallus)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Sus scrofa)
Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-16)
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