Translocation of p-STAT1:p-STAT1 dimer to nucleus

Stable Identifier
R-HSA-913529
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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IFNA-activated-factor (AAF) translocates to nucleus and then promotes the expression of a distinct set of gamma activated sequence (GAS)-driven genes like IRF1. IRF1, in turn, induces the transcription of ISG15, ISG54 and IFI6 genes. This second pathway of STAT1 homodimer formation is primarily activated by IFNG and is likely to account for some of the functional overlap between type I and type II IFNs.

Literature References
PubMed ID Title Journal Year
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Shuai, K, Horvath, CM, Huang, LH, Qureshi, SA, Cowburn, D, Darnell JE, Jr

Cell 1994
Participants
Participant Of
Orthologous Events
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