Reactome | IFIH1 [cytosol]

IFIH1 [cytosol]

Stable Identifier

R-HSA-913536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MDA5, Interferon-induced helicase C domain-containing protein 1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - MAVS interacts with RIPK1 and FADD (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
      - Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Interaction of PCBP2 with MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS (Homo sapiens)
        
        DDX58, IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:K48polyUb-MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - TRAF3-dependent IRF activation pathway (Homo sapiens)
      - Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of IRF3,IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of TRAF3 to MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - TBK1 or IKBKE forms homodimers (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKK epsilon) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - TRAF6 mediated IRF7 activation (Homo sapiens)
      - Phosphorylation and release of IRF7 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Phosphorylation of TBK1/IKBKE (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of IRF7 to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of TANK to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - TBK1, IKBKE form homodimers (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - TRAF6 mediated NF-kB activation (Homo sapiens)
      - Activation of IKK by MEKK1 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - Interaction of MEKK1 with TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - viral dsRNA binds IFIH1:TKFC (Homo sapiens)
      - IFIH1:TKFC [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
      - viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
      - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ovarian tumor domain proteases (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] (Homo sapiens)
        
        viral dsRNA:IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
        
        USP17L1,USP17L2:RCE1, CDC25A, DDX58, IFIH1 [cytosol] (Homo sapiens)
        
        RCE1, CDC25A, DDX58, IFIH1 [cytosol] (Homo sapiens)
        
        IFIH1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYX4 IFIH1

Gene Names

IFIH1, MDA5, RH116

Chain

chain:1-1025

Reference Genes

BioGPS Gene:64135 IFIH1

COSMIC (genes):IFIH1 IFIH1

CTD Gene:64135 IFIH1

dbSNP Gene:64135 IFIH1

ENSEMBL:ENSG00000115267 IFIH1

HGNC:18873 IFIH1

KEGG Gene (Homo sapiens):64135 IFIH1

Monarch:64135 IFIH1

NCBI Gene:64135 IFIH1

OMIM:606951 IFIH1

UCSC:Q9BYX4 IFIH1

Reference Transcript

RefSeq:NM_022168.3 IFIH1

Other Identifiers

0006420725

11724346_a_at

11761686_at

1555464_at

16904365

219209_at

2584208

2584209

2584210

2584211

2584213

2584215

2584216

2584218

2584219

2584220

2584221

2584222

2584223

2584224

2584225

2584226

2584227

2584228

2584229

2584230

2584234

2584235

2584236

2584238

2584239

2584240

2584241

2584242

51920_at

64135

8056285

GE62756

GO:0000166

GO:0002376

GO:0003674

GO:0003677

GO:0003723

GO:0003724

GO:0003725

GO:0003727

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006464

GO:0006950

GO:0007165

GO:0008150

GO:0008270

GO:0009597

GO:0009615

GO:0016032

GO:0016579

GO:0016787

GO:0016887

GO:0016925

GO:0032480

GO:0032727

GO:0032728

GO:0032755

GO:0032760

GO:0034344

GO:0039528

GO:0039530

GO:0042802

GO:0043021

GO:0043167

GO:0043226

GO:0044403

GO:0045087

GO:0046872

GO:0051607

GO:0060760

GO:0071360

GO:0098586

HMNXSV003051681

Hs2Affx.1.318.S1_3p_at

ILMN_1781373

PH_hs_0024506

TC02002481.hg

g11545921_3p_at

Participates

as a member of

as a component of

Other forms of this molecule

PolyUb-IFIH1 [cytosol]

K48polyUb-IFIH1 [cytosol]

Inferred To

IFIH1 [cytosol] (Bos taurus)

IFIH1 [cytosol] (Sus scrofa)

helF [cytosol] (Dictyostelium discoideum)

Ifih1 [cytosol] (Mus musculus)

Ifih1 [cytosol] (Rattus norvegicus)

ifih1 [cytosol] (Danio rerio)

ifih1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_071451.2

Guide to Pharmacology - Targets

2921

OpenTargets

ENSG00000115267

GeneCards

Q9BYX4

HPA

ENSG00000115267-IFIH1

Ensembl

ENSP00000408450, ENSP00000497271, ENST00000421365, ENST00000649979, ENSG00000115267

PRO

Q9BYX4

Pharos - Targets

Q9BYX4

Orphanet

22885

HMDB Protein

HMDBP11796

PDB

7JL2, 4GL2, 2RQB, 3GA3, 7JL0, 3B6E

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.775	7
UniProt:P05161 ISG15	4	K164-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653745) ISG15 [cytosol] (R-HSA-936552) ISG15 [nucleoplasm] (R-HSA-5653665) K168-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653744)	0.623	7
UniProt:P0DTC5 M	8	M [virion membrane] (R-COV-9694320) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [virion membrane] (R-COV-9694385)	0.621	3
UniProt:Q3LXA3 TKFC	1	TKFC [cytosol] (R-HSA-918185)	0.616	5
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.543	6
UniProt:Q14164 IKBKE	4	p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278)	0.499	2

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