GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens

Stable Identifier
R-HSA-913675
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Addition of GalNAc to mucins to form the Tn antigen
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The family of UDP GalNAc:polypeptide N acetylgalactosaminyltransferases (GalNAc transferases, GALNTs) carry out the addition of N acetylgalactosamine on serine, threonine or possibly tyrosine residues on a wide variety of proteins, and most commonly associated with mucins (Wandall et al. 1997). This reaction takes place in the Golgi apparatus (Rottger et al. 1998). There are 20 known members of the GALNT family, 15 of which have been characterised and 5 candidate members which are thought to belong to this family based on sequence similarity (Bennett et al. 2012). The GALNT-family is classified as belonging to CAZy family GT27.

Literature References
PubMed ID Title Journal Year
9394011 Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus

Röttger, S, White, J, Wandall, HH, Olivo, JC, Stark, A, Bennett, EP, Whitehouse, C, Berger, EG, Clausen, H, Nilsson, T

J Cell Sci 1998
22183981 Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family

Bennett, EP, Mandel, U, Clausen, H, Gerken, TA, Fritz, TA, Tabak, LA

Glycobiology 2012
9295285 Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3

Wandall, HH, Hassan, H, Mirgorodskaya, E, Kristensen, AK, Roepstorff, P, Bennett, EP, Nielsen, PA, Hollingsworth, MA, Burchell, J, Taylor-Papadimitriou, J, Clausen, H

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
polypeptide N-acetylgalactosaminyltransferase activity of GALNTs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created