Reactome | MAVS [mitochondrial outer membrane]

MAVS [mitochondrial outer membrane]

Stable Identifier

R-HSA-913730

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

IPS-1, Interferon beta promoter stimulator-1 (IPS-1), Mitochondrial antiviral signaling (MAVS)

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        PKR binds activating host RNA (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        PKR binds viral dsRNA (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - MAVS binds TOMM70 (Homo sapiens)
      - MAVS [mitochondrial outer membrane] (Homo sapiens)
      - MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
      - MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
      - Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - MAVS interacts with RIPK1 and FADD (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Processing of caspases (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of IKK complex (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:RIP-1/FADD:Casp-8/10 prodomain [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
      - Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
        
        ATG5:ATG12:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 [mitochondrial outer membrane] (Homo sapiens)
        
        ATG5:ATG12:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Interaction of PCBP2 with MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS:NLRX1 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - TRAF3-dependent IRF activation pathway (Homo sapiens)
      - Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of IRF3,IRF7 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of TRAF3 to MAVS (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - TBK1 or IKBKE forms homodimers (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - TRAF6 mediated IRF7 activation (Homo sapiens)
      - Phosphorylation and release of IRF7 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Phosphorylation of TBK1/IKBKE (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of IRF7 to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xpS172-TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of TANK to TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - TBK1, IKBKE form homodimers (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - TRAF6 mediated NF-kB activation (Homo sapiens)
      - Activation of IKK by MEKK1 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - Interaction of MEKK1 with TRAF6 (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane] (Homo sapiens)
        
        dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
    - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
      - MAVS [mitochondrial outer membrane] (Homo sapiens)
      - MAVS:NLRX1 [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
      - viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ovarian tumor domain proteases (Homo sapiens)
      - OTUD5 deubiquitinates TRAF3 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        MAVS [mitochondrial outer membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z434 MAVS

Gene Names

MAVS, IPS1, KIAA1271, VISA

Chain

chain:1-540

Reference Genes

BioGPS Gene:57506 MAVS

COSMIC (genes):MAVS MAVS

CTD Gene:57506 MAVS

dbSNP Gene:57506 MAVS

ENSEMBL:ENSG00000088888 MAVS

ENSEMBL:ENSG00000088888.18 MAVS

HGNC:29233 MAVS

KEGG Gene (Homo sapiens):57506 MAVS

Monarch:57506 MAVS

NCBI Gene:57506 MAVS

OMIM:609676 MAVS

UCSC:Q7Z434 MAVS

Reference Transcript

Other Identifiers

11727037_at

11727038_a_at

11727039_at

11727040_at

11748041_a_at

11748283_a_at

11752037_a_at

16911077

220305_PM_at

220305_at

226495_PM_at

226495_at

229741_PM_at

229741_at

231829_PM_at

231829_at

3874499

3874503

3874504

3874505

3874506

3874507

3874509

3874510

3874511

3874512

3874513

3874515

3874516

3874517

3874518

3874519

3874520

3874521

3874522

3874523

3874524

3874525

3874526

3874527

3874528

3874529

3874531

3874532

57506

59318_at

60021_at

60494_at

76826_at

80283_at

8060705

88885_at

A_19_P00319295

A_19_P00319465

A_19_P00329711

A_19_P00331109

A_19_P00812044

A_23_P68539

A_24_P164854

A_24_P928798

A_33_P3244021

A_33_P3244026

A_33_P3272527

GE538835

GE87674

GO:0000151

GO:0001934

GO:0002218

GO:0002230

GO:0002376

GO:0002735

GO:0002753

GO:0005515

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0006351

GO:0006355

GO:0006886

GO:0006913

GO:0007031

GO:0007165

GO:0016020

GO:0019901

GO:0023052

GO:0031966

GO:0032481

GO:0032727

GO:0032728

GO:0032755

GO:0032757

GO:0032760

GO:0035591

GO:0036211

GO:0039552

GO:0042307

GO:0042742

GO:0042802

GO:0043123

GO:0043226

GO:0045071

GO:0045087

GO:0045944

GO:0050700

GO:0050896

GO:0051091

GO:0051607

GO:0060090

GO:0060337

GO:0060340

GO:0060760

GO:0065003

GO:0070585

GO:0071360

GO:0071651

GO:0071660

GO:0098542

GO:0098772

GO:0140374

GO:0140677

GO:0140693

GO:1900063

GO:1900227

HMNXSV003055051

Hs.134883.0.A1_3p_at

Hs.183669.0.A1_3p_at

Hs.183669.1.A1_3p_at

ILMN_1800152

ILMN_2131493

PH_hs_0022531

PH_hs_0040123

PH_hs_0040592

TC20000043.hg

TC20001069.hg

g13128977_3p_at

Participates

as a component of

as an input of

This entity regulates

Positively

Other forms of this molecule

K48polyUb-MAVS [mitochondrial outer membrane]

Inferred To

MAVS [mitochondrial outer membrane] (Bos taurus)

MAVS [mitochondrial outer membrane] (Canis familiaris)

MAVS [mitochondrial outer membrane] (Gallus gallus)

MAVS [mitochondrial outer membrane] (Sus scrofa)

mavs [mitochondrial outer membrane] (Xenopus tropicalis)

wu:fj20d04 [mitochondrial outer membrane] (Danio rerio)

Mavs [mitochondrial outer membrane] (Mus musculus)

Mavs [mitochondrial outer membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001193420.1, NP_065797.2

OpenTargets

ENSG00000088888

HPA

ENSG00000088888-MAVS

GeneCards

Q7Z434

Ensembl

ENSP00000401980, ENST00000416600, ENSG00000088888, ENST00000428216, ENSP00000413749

PRO

Q7Z434

Pharos - Targets

Q7Z434

PDB

2MS7, 5JEK, 3RC5, 7DNI, 2MS8, 4Z8M, 3J6J, 4P4H, 3J6C, 2VGQ

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.956	19
UniProt:Q86WV6 STING1	5	TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.839	9
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.775	7
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.77	4
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.742	5
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.733	11
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.723	6
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.71	4
UniProt:P0DTD8 NS7B			0.632	3
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.591	6
UniProt:Q07021 C1QBP	3	C1QBP [plasma membrane] (R-HSA-158123) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [cytosol] (R-HSA-9645690)	0.589	5
UniProt:O43353 RIPK2	2	RIPK2 [cytosol] (R-HSA-168402) Ub-209-RIPK2 [cytosol] (R-HSA-706483)	0.576	3
UniProt:Q13137 CACO2			0.576	3
UniProt:P42224 STAT1	7	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.576	3
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.564	2
UniProt:P36957 DLST	2	DLST [mitochondrial matrix] (R-HSA-6792574) Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993)	0.556	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.556	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.556	4
IntAct:EBI-25890541 CCSB			0.556	3
UniProt:P0DTD1-PRO_0000449623 REP			0.544	2
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.543	4
UniProt:P59636 9b	2	9b [mitochondrial outer membrane] (R-COV-9685182) 9b [cytosol] (R-COV-9689378)	0.543	5
UniProt:O75746 SLC25A12	2	SLC25A12 [mitochondrial intermembrane space] (R-HSA-1307794) SLC25A12 [mitochondrial inner membrane] (R-HSA-372470)	0.537	3
UniProt:Q6WB96 M22			0.524	4
UniProt:A2T3M4 NSP1			0.524	4
UniProt:Q9Y6K5 OAS3	1	OAS3 [cytosol] (R-HSA-1015672)	0.499	2
UniProt:P46379 BAG6	1	BAG6 [cytosol] (R-HSA-201567)	0.499	2
UniProt:Q7TFA1 NS7B			0.499	2
UniProt:Q14139 UBE4A	1	UBE4A [cytosol] (R-HSA-976022)	0.499	2
UniProt:Q13568 IRF5	1	IRF5 [cytosol] (R-HSA-1015676)	0.499	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2
UniProt:P27958 Genome polyprotein	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.463	2
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407-STAT6 [cytosol] (R-HSA-3249369) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.462	3

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