Reactome | 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2

14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2

Stable Identifier

R-HSA-913993

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2

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RAP1GAP2 binds 14-3-3 proteins beta and zeta, inhibiting its GAP activity for Rap1. This effect is diminished by Ser-7 phosphorylation of RAP1GAP2 by cGMP- and cAMP-dependent protein kinases (PKG and PKA respectively), which inhibits the binding of 14-3-3 proteins beta and zeta to Rap1GAP2. 14-3-3 binding does not appear to alter the GTPase-activating function of Rap1GAP2 in vitro, but attenuates Rap1GAP2 mediated inhibition of cell adhesion (Hoffmeister et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18039662	Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets Neumüller, O, Riha, P, Schultess, J, Danielewski, O, Smolenski, AP, Hoffmeister, M	J Biol Chem	2008