PKA/PKG phosphorylate Rap1GAP2

Stable Identifier
R-HSA-913996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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cGMP and cAMP dependent protein kinases (PKG and PKA respectively) phosphorylate the Rap1 GTPase activating RAP1GAP2 at serine 7 (Schultess et al. 2007). This reduces the binding of inhibitory 14-3-3 proteins to RAP1GAP2.

Literature References
PubMed ID Title Journal Year
15632203 Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets

Schultess, J, Danielewski, O, Smolenski, AP

Blood 2005
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Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PKA catalytic subunits, PKG type I [cytosol]
Physical Entity
Activity
Orthologous Events
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