Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein

Stable Identifier
R-HSA-914010
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). They catalyse the addition of N-acetylglucosamine to the T antigen to form the Core 3 glycoprotein (Togayachi et al, 2006). Thie reaction occurs in the Golgi.

Literature References
PubMed ID Title Journal Year
15560372 Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase

Zheng, H, Li, Y, Ji, C, Li, J, Zhang, J, Yin, G, Xu, J, Ye, X, Wu, M, Zou, X, Gu, S, Xie, Y, Mao, Y

Mol Biol Rep 2004
17113861 Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif

Togayachi, A, Sato, T, Narimatsu, H

Methods Enzymol 2006
11283017 Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids

Togayachi, A, Akashima, T, Ookubo, R, Kudo, T, Nishihara, S, Iwasaki, H, Natsume, A, Mio, H, Inokuchi, J, Irimura, T, Sasaki, K, Narimatsu, H

J Biol Chem 2001
15486459 Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family

Huang, C, Zhou, J, Wu, S, Shan, Y, Teng, S, Yu, L

Glycoconj J 2004
11042166 Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family

Shiraishi, N, Natsume, A, Togayachi, A, Endo, T, Akashima, T, Yamada, Y, Imai, N, Nakagawa, S, Koizumi, S, Sekine, S, Narimatsu, H, Sasaki, K

J Biol Chem 2001
9417100 Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains

Kolbinger, F, Streiff, MB, Katopodis, AG

J Biol Chem 1998
15620693 A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer

Ishida, H, Togayachi, A, Sakai, T, Iwai, T, Hiruma, T, Sato, T, Okubo, R, Inaba, N, Kudo, T, Gotoh, M, Shoda, J, Tanaka, N, Narimatsu, H

FEBS Lett 2005
11821425 Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans

Iwai, T, Inaba, N, Naundorf, A, Zhang, Y, Gotoh, M, Iwasaki, H, Kudo, T, Togayachi, A, Ishizuka, Y, Nakanishi, H, Narimatsu, H

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity of B3GNTs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created