GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins

Stable Identifier
R-HSA-914012
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein
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The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltransferase which mediates core 2 O-glycan branching by the addition of N-acetylgalactosamine, an important step in mucin-type biosynthesis. There are 3 defined members in humans, 1, 3 and 4 (Bierhuizen and Fukuda, 1992; Yeh et al, 1999; Schwientek et al, 2000). Two members (6 and 7) may be part of the family based on sequence similarity.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity of GCNTs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created