Reactome: A Curated Pathway Database

SHP1 and SHP2 dephosphorylate Y628 of IL3RB

Stable Identifier
R-HSA-914036
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Synthetic phosphopeptides based on Bc were dephosphorylated by SHP1 and SHP2, peptides phosphorylated at Y628 were the best substrate followed by those phosphorylated at Y766.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] protein tyrosine phosphatase activity (0004725)
Orthologous Events